ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name DBH_intron5_C/T_TaqI
Type point mutation
Location intron 5
Related Gene DBH
No. of Study 8 (significant: 4; non-significant 4; trend: 0)

Variant related studies (count: 8)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Bhaduri N, 2005 C/T allelic HHRR P-value=0.7082, X2(df=1)=0.14, RR=0....... allelic HHRR P-value=0.7082, X2(df=1)=0.14, RR=0.93 More... suggested lack of significant association between transmissi...... suggested lack of significant association between transmission of this polymorphism and ADHD More... Non-significant
Inkster B, 2004 C/T 2 allele TDT P-value=0.31, X2=1.03, df=1; TDT P-value=0.12...... TDT P-value=0.31, X2=1.03, df=1; TDT P-value=0.12, X2=2.37, df=1 of males; TDT P-value=0.37, X2=0.82, df=1 of females, for 2 allele in the family-based sample. TDT P-value=0.057, X2=3.63, df=1 for 2 allele in the case-control sample More... the TDT analysis showed weak over-transmission of the DBH Ta...... the TDT analysis showed weak over-transmission of the DBH TaqI 2 allele in both samples; the family-based analysis stratified by proband gender revealed that only males were contributing to the biased transmission observed; no gender-specific effects for the case-control sample were observed More... Non-significant
Hawi Z, 2003 C/T HHRR P-value=0.0027, X2=9, RR=1.38 for allele1 HHRR P-value=0.0027, X2=9, RR=1.38 for allele1 showed highly significant association with ADHD showed highly significant association with ADHD Significant
Wigg K, 2002 C/T T TDT allele test P-value=0.07 (one-sided) TDT allele test P-value=0.07 (one-sided) no significant evidence for biased transmission no significant evidence for biased transmission Non-significant
Kirley A, 2002 C/T HHRR: P-value=0.0027 (RR=1.38, OR=1.87); TDT: P-value=0.01 (...... HHRR: P-value=0.0027 (RR=1.38, OR=1.87); TDT: P-value=0.01 (OR=1.88); TDT by presence of family history: P-value=0.307 (OR[95%CI]=2.44[0.59-10.04]); TDT of Paternal and Maternal transmissions: P-value=0.98 (OR[95%CI]=1.01[0.36-2.90]) More... Significant preferential transmission Significant preferential transmission Significant
Smith KM, 2003 Allele 1: no site; Allele 2: TaqI recognition site A1 Genotypic chi-square P-value=0.064, Allelic chi-square P-val...... Genotypic chi-square P-value=0.064, Allelic chi-square P-value=0.018; OR=1.96, RR=1.33 More... A1 allele was observed more frequently in the ADHD compared ...... A1 allele was observed more frequently in the ADHD compared to the control group; DBH TaqI A polymorphism is significantly associated with ADHD More... Significant
Roman T, 2002 C/T HRR analysis: P-value=0.03 for whole sample of ADHD probands...... HRR analysis: P-value=0.03 for whole sample of ADHD probands, P-value=0.42 for families with ADHD parental diagnosis (FH+), P-value=0.01 for families with no familial history of ADHD (FH-) More... The A2 allele was significantly more transmitted than not tr...... The A2 allele was significantly more transmitted than not transmitted More... Significant
Payton A, 2001 G/T allelic TDT P-value=0.49 allelic TDT P-value=0.49 there was no evidence of preferential transmission of any ma...... there was no evidence of preferential transmission of any marker allele More... Non-significant