ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STX6
Approved Name	syntaxin 6
Location	1q25.3
Position	chr1:180941861-180992047, -1
External Links	HGNC: 11441 Entrez Gene: 10228 Ensembl: ENSG00000135823 UCSC: uc021pfr.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	biological process	IEA	3

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	molecular function	IPI	1015
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[10506127]	99
GO:0016021	integral to membrane	cellular component	IEA	932
GO:0032588	trans-Golgi network membrane	cellular component	ISS	7
GO:0005794	Golgi apparatus	cellular component	IDA[19224922]	174
GO:0000139	Golgi membrane	cellular component	IEA	106
GO:0030136	clathrin-coated vesicle	cellular component	TAS[9697774]	9
GO:0006886	intracellular protein transport	biological process	IEA	45
GO:0005769	early endosome	cellular component	IDA[10506127]	27
GO:0005484	SNAP receptor activity	molecular function	IEA	13
GO:0005886	plasma membrane	cellular component	TAS[9697774]	839
GO:0042147	retrograde transport, endosome to Golgi	biological process	IMP[19224922]	6
GO:0007032	endosome organization	biological process	IEA	7
GO:0006906	vesicle fusion	biological process	IPI[10506127]	1
GO:0031201	SNARE complex	cellular component	IDA[19620288]	13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04130	SNARE interactions in vesicular transport	20

Genes shared at least 5 GO terms with STX6 (count: 16)

Gene Symbol	Pathway Count	Pathway List
STX16	8	protein binding; integral to membrane; Golgi apparatus; Golgi membrane; intracellular protein transport; SNAP receptor activity; retrograde transport, endosome to Golgi; SNARE complex;
STX4	7	protein binding; perinuclear region of cytoplasm; integral to membrane; intracellular protein transport; SNAP receptor activity; plasma membrane; SNARE complex;
STX5	7	integral to membrane; Golgi apparatus; Golgi membrane; intracellular protein transport; SNAP receptor activity; retrograde transport, endosome to Golgi; SNARE complex;
STX1A	6	protein binding; integral to membrane; intracellular protein transport; SNAP receptor activity; plasma membrane; SNARE complex;
SORT1	6	perinuclear region of cytoplasm; integral to membrane; Golgi apparatus; clathrin-coated vesicle; early endosome; plasma membrane;
GOSR1	6	integral to membrane; Golgi apparatus; Golgi membrane; SNAP receptor activity; retrograde transport, endosome to Golgi; SNARE complex;
GJA1	5	protein binding; Golgi apparatus; Golgi membrane; early endosome; plasma membrane;
TMED10	5	protein binding; integral to membrane; Golgi apparatus; intracellular protein transport; plasma membrane;
RAB14	5	protein binding; perinuclear region of cytoplasm; Golgi membrane; early endosome; plasma membrane;
STX3	5	protein binding; integral to membrane; intracellular protein transport; SNAP receptor activity; SNARE complex;
PTCH1	5	protein binding; perinuclear region of cytoplasm; integral to membrane; Golgi apparatus; plasma membrane;
STX18	5	protein binding; integral to membrane; Golgi membrane; intracellular protein transport; SNAP receptor activity;
STX7	5	perinuclear region of cytoplasm; integral to membrane; intracellular protein transport; SNAP receptor activity; SNARE complex;
CALN1	5	perinuclear region of cytoplasm; integral to membrane; trans-Golgi network membrane; Golgi apparatus; plasma membrane;
PARM1	5	integral to membrane; Golgi apparatus; Golgi membrane; early endosome; plasma membrane;
YKT6	5	Golgi apparatus; Golgi membrane; SNAP receptor activity; retrograde transport, endosome to Golgi; SNARE complex;

Genes shared at least 2 KEGG pathways with STX6 (count: 0)

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Region: chr1:180941861..180992047 View in gBrowse