ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STX6
Approved Name	syntaxin 6
Location	1q25.3
Position	chr1:180941861-180992047, -
External Links	HGNC: 11441 Entrez Gene: 10228 Ensembl: ENSG00000135823 UCSC: uc010pnq.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	Biological Process		49

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000139	Golgi membrane	Cellular Component		95
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[10506127]	87
GO:0042147	retrograde transport, endosome to Golgi	Biological Process	IMP[19224922]	5
GO:0032588	trans-Golgi network membrane	Cellular Component		5
GO:0031201	SNARE complex	Cellular Component	IDA[19620288]	13
GO:0030136	clathrin-coated vesicle	Cellular Component	TAS[9697774]	9
GO:0016021	integral to membrane	Cellular Component		845
GO:0007032	endosome organization	Biological Process		7
GO:0006906	vesicle fusion	Biological Process	IPI[10506127]	1
GO:0006886	intracellular protein transport	Biological Process		43
GO:0005886	plasma membrane	Cellular Component	TAS[9697774]	772
GO:0005794	Golgi apparatus	Cellular Component	IDA[19224922]	157
GO:0005769	early endosome	Cellular Component	IDA[10506127]	25
GO:0005515	protein binding	Molecular Function		910
GO:0005484	SNAP receptor activity	Molecular Function		13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04130	SNARE interactions in vesicular transport	20

Genes shared at least 5 GO terms with STX6 (count: 20)

Gene Symbol	Pathway Count	Pathway List
STX16	9	Golgi membrane; Golgi vesicle transport; retrograde transport, endosome to Golgi; SNARE complex; integral to membrane; intracellular protein transport; Golgi apparatus; protein binding; SNAP receptor activity;
GOSR1	7	Golgi membrane; Golgi vesicle transport; retrograde transport, endosome to Golgi; SNARE complex; integral to membrane; Golgi apparatus; SNAP receptor activity;
STX5	7	Golgi membrane; retrograde transport, endosome to Golgi; SNARE complex; integral to membrane; intracellular protein transport; Golgi apparatus; SNAP receptor activity;
STX4	7	perinuclear region of cytoplasm; SNARE complex; integral to membrane; intracellular protein transport; plasma membrane; protein binding; SNAP receptor activity;
RAB14	6	Golgi membrane; perinuclear region of cytoplasm; Golgi vesicle transport; plasma membrane; early endosome; protein binding;
STX18	6	Golgi membrane; Golgi vesicle transport; integral to membrane; intracellular protein transport; protein binding; SNAP receptor activity;
YKT6	6	Golgi membrane; Golgi vesicle transport; retrograde transport, endosome to Golgi; SNARE complex; Golgi apparatus; SNAP receptor activity;
SORT1	6	perinuclear region of cytoplasm; clathrin-coated vesicle; integral to membrane; plasma membrane; Golgi apparatus; early endosome;
STX7	6	perinuclear region of cytoplasm; Golgi vesicle transport; SNARE complex; integral to membrane; intracellular protein transport; SNAP receptor activity;
TMED10	6	Golgi vesicle transport; integral to membrane; intracellular protein transport; plasma membrane; Golgi apparatus; protein binding;
STX1A	6	SNARE complex; integral to membrane; intracellular protein transport; plasma membrane; protein binding; SNAP receptor activity;
COG7	5	Golgi membrane; Golgi vesicle transport; intracellular protein transport; Golgi apparatus; protein binding;
COPB1	5	Golgi membrane; Golgi vesicle transport; intracellular protein transport; plasma membrane; protein binding;
GJA1	5	Golgi membrane; plasma membrane; Golgi apparatus; early endosome; protein binding;
PARM1	5	Golgi membrane; integral to membrane; plasma membrane; Golgi apparatus; early endosome;
CALN1	5	perinuclear region of cytoplasm; trans-Golgi network membrane; integral to membrane; plasma membrane; Golgi apparatus;
PTCH1	5	perinuclear region of cytoplasm; integral to membrane; plasma membrane; Golgi apparatus; protein binding;
COG3	5	Golgi vesicle transport; intracellular protein transport; plasma membrane; Golgi apparatus; protein binding;
SCAMP2	5	Golgi vesicle transport; trans-Golgi network membrane; integral to membrane; Golgi apparatus; protein binding;
STX3	5	SNARE complex; integral to membrane; intracellular protein transport; protein binding; SNAP receptor activity;

Genes shared at least 2 KEGG pathways with STX6 (count: 0)

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Region: chr1:180941861..180992047 View in gBrowse