ADHDgene Database

SNP Report

Basic Info

Name	rs6039806 dbSNP Ensembl
Location	Chr20:10258654(Fwd)
Variant Alleles	C/A
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript	intron_variant(ENST00000254976; ENST00000304886; ENST00000421143; ENST00000453544; ENST00000430336) nc_transcript_variant(ENST00000453544; ENST00000421143; ENST00000492814) non_coding_exon_variant(ENST00000492814)
No. of Studies	3 (significant: 1; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
Ilott NE, 2010		QTDT AT P-value=0.96, X²=0, df=1, QTDT AW P-value...... QTDT AT P-value=0.96, X²=0, df=1, QTDT AW P-value=0.99, X²=0, df=1 at age 2; QTDT AT P-value=0.97, X²=0.08, df=1, QTDT AW P-value=0.52, X²=0.41, df=1 at age 3 More...	no significant association no significant association	Non-significant
Feng Y, 2005(b)	C/A	allelic TDT P-value=0.302, X²=1.067 in Irvine sam...... allelic TDT P-value=0.302, X²=1.067 in Irvine sample; allelic TDT P-value=0.005, X²=7.848 in Toronto sample; TDT P-value=0.493, X²(1df)=0.471 in the Toronto sample by Inattentive subtype; TDT P-value=0.346, X²(1df)=0.889 in the Toronto sample by Hyperactive/impulsive subtype; TDT P-value=0.007, X²(1df)=7.218 in the Toronto sample by Combined subtype More...	there was significant evidence for biased transmission in th...... there was significant evidence for biased transmission in the Toronto sample; TDT test was not significant in the Irvine sample; the observed evidence for biased transmission was not significant in the inattentive or hyperactive/impulsive subtype, but significant in the combined subtype in the Toronto sample More...	Significant
Brookes K, 2006	A/C	UNPHASED TDT P-value=0.555; WHAP TDT P-value=0.607 UNPHASED TDT P-value=0.555; WHAP TDT P-value=0.607	no significant association was observed no significant association was observed	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)

Approved Symbol	Approved Name	Location
SNAP25-AS1	SNAP25 antisense RNA 1	20p12.2

SNPs in LD with rs6039806 (count: 5) View in gBrowse (chr20:10253082..10277452 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs362549	intron_variant; nc_transcript_variant	3(2/1/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.878[CHD]; 0.847[GIH]; 1.0[JPT]; 0.963[LWK]; 0.913[MEX]; 0.902[MKK]; 0.954[TSI]; 1.0[YRI]
rs362987	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	5(1/4/0)	1.0[CEU]; 0.847[GIH]; 0.873[MEX]; 0.931[TSI]

rs_ID	Functional Annotation	r²[population]
rs6039807	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.877[CHD]; 0.954[GIH]; 1.0[JPT]; 0.915[MEX]; 0.954[TSI]
rs362574	intron_variant; nc_transcript_variant; upstream_gene_variant	0.851[CEU]; 0.851[TSI]
rs6108461	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]