ADHDgene Database

SNP Report

Basic Info

Name	rs362988 dbSNP Ensembl
Location	Chr20:10281370(Fwd)
Variant Alleles	G/A
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000421143; ENST00000254976; ENST00000453544; ENST00000495883; ENST00000304886) nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883)
No. of Studies	3 (significant: 1; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
Guan L, 2009		single SNP association analyses: Nominal P-value=0.033, Empi...... single SNP association analyses: Nominal P-value=0.033, Empirical P-value=0.505 for ADHD-I More...	non-significant for ADHD, but achieve nominal significance f...... non-significant for ADHD, but achieve nominal significance for ADHD-I More...	Significant
Sarkar, K., 2012	A/G	allelic P-value=0.31, X²=1.01 for case-control, P...... allelic P-value=0.31, X²=1.01 for case-control, P-value=0.47, X²=0.52 for family-based; genotypic P-value=0.47, X²=1.49 for case-control, P-value=0.59, X²=1.04 for family-based; X²=1.5, TDT P-value=0.22, Relative risk (95% CI)=0.6 (0.35¨C1.1) More...	Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. rs362988 'G' allele showed a bias in transmission though the difference was statistically insignificant. More...	Non-significant
Nyman ES, 2007		No available information. No available information.	No evidence of association was seen. No evidence of association was seen.	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)

Approved Symbol	Approved Name	Location
SNAP25-AS1	SNAP25 antisense RNA 1	20p12.2

SNPs in LD with rs362988 (count: 1) View in gBrowse (chr20:10281370..10282027 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.