ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs362998 dbSNP Ensembl
Location	Chr20:10277621(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000430336) intron_variant(ENST00000421143; ENST00000453544) nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883) non_coding_exon_variant(ENST00000495883) synonymous_variant(ENST00000254976; ENST00000304886)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Feng Y, 2005(b)	C/G		allelic TDT P-value=0.439, X²=0.6 in Irvine sampl...... allelic TDT P-value=0.439, X²=0.6 in Irvine sample; allelic TDT P-value=0.019, X²=5.488 in Toronto sample; TDT P-value=0.763, X²(1df)=0.091 in the Toronto sample by Inattentive subtype; TDT P-value=0.014, X²(1df)=6 in the Toronto sample by Combined subtype More...	there was significant evidence for biased transmission in th...... there was significant evidence for biased transmission in the Toronto sample; TDT test was not significant in the Irvine sample; the observed evidence for biased transmission was not significant in the inattentive or hyperactive/impulsive subtype, but significant in the combined subtype in the Toronto sample More...	Significant
Kim JW, 2007	C/T	T	Combined TDT P-value=0.09 (OR=1.36); Single marker analysis ...... Combined TDT P-value=0.09 (OR=1.36); Single marker analysis FBAT P-value=0.446; Exploratory analyses FBAT P-value=0.592 for co-morbid CD, P-value=0.179 for co-morbid MDD, P-value=0.345 for co-morbid BD More...	No association was found between ADHD or co-morbidities of A...... No association was found between ADHD or co-morbidities of ADHD and this SNP More...	Non-significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)

Genes from other sources (count: 1)

Approved Symbol	Approved Name	Location
SNAP25-AS1	SNAP25 antisense RNA 1	20p12.2

SNPs in LD with rs362998 (count: 17) View in gBrowse (chr20:10247685..10280439 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 3)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs2076240	intron_variant; nc_transcript_variant	1(0/1/0)	1.0[CEU]; 0.924[CHB]; 1.0[JPT]; 0.947[YRI]
rs362585	intron_variant; nc_transcript_variant	1(1/0/0)	0.874[ASW]; 0.924[CHB]; 0.959[CHD]; 1.0[JPT]; 0.854[YRI]
rs3025873	intron_variant; nc_transcript_variant	1(1/0/0)	1.0[CHB]; 1.0[CHD]; 1.0[JPT]

LD-proxies (count: 14)

rs_ID	Functional Annotation	r²[population]
rs6133845	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs362999	intron_variant; nc_transcript_variant	1.0[CEU]; 0.833[CHB]; 1.0[JPT]; 0.941[YRI]
rs363004	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.971[LWK]; 0.934[MEX]; 1.0[TSI]; 1.0[YRI]
rs2284299	intron_variant; nc_transcript_variant	1.0[CEU]; 0.92[CHB]; 1.0[JPT]; 0.945[YRI]
rs2284297	intron_variant; nc_transcript_variant	1.0[CEU]; 0.952[GIH]; 0.87[TSI]
rs8116632	intron_variant; nc_transcript_variant	0.818[JPT]
rs2284300	intron_variant; nc_transcript_variant	1.0[CEU]; 0.924[CHB]; 1.0[CHD]; 0.952[GIH]; 1.0[JPT]; 0.801[MEX]; 0.847[MKK]; 1.0[TSI]; 0.893[YRI]
rs41378446	intron_variant; nc_transcript_variant	0.828[CHD]; 0.842[YRI]
rs362590	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs362995	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 0.841[CHB]; 0.874[JPT]
rs362582	intron_variant; nc_transcript_variant; upstream_gene_variant	0.924[CHB]; 0.959[CHD]; 1.0[JPT]
rs2076239	intron_variant; nc_transcript_variant	1.0[CEU]; 0.924[CHB]; 1.0[JPT]; 0.947[YRI]
rs362592	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[ASW]; 0.879[CEU]; 1.0[CHB]; 0.92[CHD]; 0.938[GIH]; 1.0[JPT]; 0.932[MEX]; 0.958[MKK]; 1.0[TSI]; 1.0[YRI]
rs362991	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.971[LWK]; 1.0[MEX]; 0.962[MKK]; 1.0[TSI]; 1.0[YRI]