Reference |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
Manor I, 2001 |
short/long |
|
genotypic HRR P-value=0.11, likelihood ratio=4.45 in the ADH......
genotypic HRR P-value=0.11, likelihood ratio=4.45 in the ADHD group, genotypic HRR P-value=0.008, likelihood ratio=9.62 in the combined triads, genotypic HRR P-value=0.004, likelihood ratio=11.25 in the ADHD subjects excluding the inattentive group; allelic HRR P-value=0.31, likelihood ratio=1.03 in all ADHD traids, allelic HRR P-value=0.069, likelihood ratio=3.81 in the combined type; HRR P-value=0.108, likelihood ratio=4.45 in the case-control analysis
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there was a decreased homozygosity of the short/short genoty......
there was a decreased homozygosity of the short/short genotype in the ADHD group but not significant; a significant decrease in homozygosity of the short/short 5-HTTLPR genotype was observed in the ADHD group compared with the HRR control group in the combined traids and in ADHD subjects excluding the inattentive group; no significant differences in 5-HTTLPR allele frequency were observed in all ADHD triads and the ADHD combined type, and a deficit of the short 5-HTTLPR allele in the ADHD group was observed; statistical significance of genotype frequencies was not obtained using a case-control design
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Significant
|
Zoroglu SS, 2002 |
short/long |
|
Fisher¡¯s exact test, allelic P-value=0.289; Pearson P-value......
Fisher¡¯s exact test, allelic P-value=0.289; Pearson P-value=0.018, X2=8.003, d.f.=2 of S/S genotype
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|
S and L alleles of 5-HTTLPR were similar between the control......
S and L alleles of 5-HTTLPR were similar between the controls and patients; the 5-HTTLPR S/S genotype was represented significantly less in the patients than in the controls
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Significant
|
Kent L, 2002 |
short/long |
long |
TDT P-value>0.05
TDT P-value>0.05
|
No significant evidence was found for biased transmission
No significant evidence was found for biased transmission
|
Non-significant
|
Langley K, 2003 |
short/long |
|
allelic ETDT P-value=0.37, X2=0.82 in the total s......
allelic ETDT P-value=0.37, X2=0.82 in the total sample; allelic ETDT P-value=0.82, X2=0.049, OR=1.04 in the case-control analysis
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there was no evidence of preferential transmission of the lo......
there was no evidence of preferential transmission of the long allele in the total sample and case-control differences were also not significant
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Non-significant
|
Beitchman JH, 2003 |
short/long |
|
Fisher's exact test P-value=0.041
Fisher's exact test P-value=0.041
|
there was a significant link between 5HTTLPR and ADHD, but n......
there was a significant link between 5HTTLPR and ADHD, but no significant association with aggression
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Significant
|
Zhao AL, 2005 |
short/long |
|
allelic and genotypic chi-square test P-value>0.05
allelic and genotypic chi-square test P-value>0.05
|
no significant associations were seen between the frequencie......
no significant associations were seen between the frequencies of any genotype or allele of 5-HTTLPR and ADHD
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Non-significant
|
Xu X, 2005(b) |
short/long |
|
allelic ETDT P-value=0.521, X2=0.412 in UK sample......
allelic ETDT P-value=0.521, X2=0.412 in UK samples; allelic ETDT P-value=0.497, X2=0.462 in Taiwanese samples; allelic ETDT P-value=0.943, X2=0.005 in combined samples; allelic HHRR P-value=0.546, X2=0.364 in UK samples; allelic HHRR P-value=0.530, X2=0.394 in Taiwanese samples; HHRR P-value=0.950, X2=0.004 in combined samples; allelic TRANSMIT P-value=0.689, X2=0.161 in UK samples; allelic TRANSMIT P-value=0.074, X2=3.192 in Taiwanese samples; allelic TRANSMIT P-value=0.696, X2=0.153 in combined samples
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|
there was no significant preferential transmission of the lo......
there was no significant preferential transmission of the long-allele in UK samples, Taiwanese samples and combined samples
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Non-significant
|
Kim SJ, 2005 |
short/long |
|
allelic TDT P-value=0.11 for ADHD pooled together, TDT P-val......
allelic TDT P-value=0.11 for ADHD pooled together, TDT P-value=0.036 for ADHD without ADHD NOS subtype; 5-HTTLPR allele frequencies: X2=2.60, df=1, P-value=0.11 compared to the previous reports [Kim et al., 2000, 2004a; Pae et al.,2003]; 5-HTTLPR allele frequencies: X2=2.70, df=2, P-value=0.60 among ADHD subtype groups excluding ADHD NOS subtype
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TDT revealed nominally significant LD between 5-HTTLPR and A......
TDT revealed nominally significant LD between 5-HTTLPR and ADHD; the frequencies of the alleles and genotypes did not differ significantly compared to the previous reports
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Significant
|
Banerjee E, 2006 |
short/long |
|
X2=0.37, df=1; P-value=0.543; HHRR X2=......
X2=0.37, df=1; P-value=0.543; HHRR X2=0, RR=1.00; TDT X2=0, OR=1.00
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revealed no significant association
revealed no significant association
|
Non-significant
|
Wigg KG, 2006 |
short/long |
|
SA TDT P-value=0.456, X2=0.556; L......
SA TDT P-value=0.456, X2=0.556; LA TDT P-value=0.419, X2=0.654; LG TDT P-value=0.893, X2=0.018; LA+LG P-value=0.519
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no evidence of biased transmission
no evidence of biased transmission
|
Non-significant
|
Li J, 2007 |
short/long |
|
Allelic TDT P-value=0.016 for ADHD, P-value=0.111 for ADHD-C......
Allelic TDT P-value=0.016 for ADHD, P-value=0.111 for ADHD-C, P-value=0.093 for ADHD-I
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|
preferential transmission of the S allele to ADHD offspring,......
preferential transmission of the S allele to ADHD offspring, but analyses of subtypes did not reach statistical significance
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|
Significant
|
Guimaraes AP, 2007 |
short/long |
|
HRR P-value=0.53 (OR=1.1[0.82-1.45]) in total samples; HRR P......
HRR P-value=0.53 (OR=1.1[0.82-1.45]) in total samples; HRR P-value=0.14 (OR=1.25[0.92-1.71]) in boys samples.
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No evidences for biased transmission of alleles for this pol......
No evidences for biased transmission of alleles for this polymorphism to the ADHD probands were observed
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Non-significant
|
Heiser P, 2007 |
short/long |
|
allelic PDT P-value=0.12
allelic PDT P-value=0.12
|
showed no statistically significant preferential transmissio......
showed no statistically significant preferential transmission of any allele
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Non-significant
|
Grevet EH, 2007 |
short/long |
|
chi-square test P-value=0.95, X2=0.69 for genotyp......
chi-square test P-value=0.95, X2=0.69 for genotype frequency, chi-square test P-value=0.34, X2=0.92 for allele frequency between ADHD and controls, chi-square test P-value=0.69, X2=1.47 for allele frequency between inattentives&combined and controls
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|
there were no significant alleles and genotypes differences ......
there were no significant alleles and genotypes differences in this case-control study
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Non-significant
|
Nyman ES, 2007 |
short/long |
|
No available information.
No available information.
|
No evidence of association was seen.
No evidence of association was seen.
|
Non-significant
|
Gizer IR, 2009 |
short/long |
|
Meta-analysis model: Random: OR=1.17, 95% CI=1.02-1.33, P-va......
Meta-analysis model: Random: OR=1.17, 95% CI=1.02-1.33, P-value=0.01; Q-statistic: P-value=0.00003, I2=66
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|
significant but modest association
significant but modest association
|
Significant
|
Xu X, 2008(a) |
short/long |
|
TDT P-value=0.27, X2=1.21, OR=1.07, for L allele;......
TDT P-value=0.27, X2=1.21, OR=1.07, for L allele; TDT P-value=0.27, X2=1.21, OR=0.93, for S allele
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were not significantly associated with ADHD
were not significantly associated with ADHD
|
Non-significant
|
Ilott NE, 2010 |
short/long |
|
QTDT AT P-value=0.57, X2=0.31, df=1, QTDT AW P-va......
QTDT AT P-value=0.57, X2=0.31, df=1, QTDT AW P-value=0.87, X2=0.03, df=1 at age 2; QTDT AT P value=0.87, X2=0.03, df=1, QTDT AW P-value=0.34, X2=0.91, df=1 at age 3
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no significant association
no significant association
|
Non-significant
|
Landaas ET, 2010 |
short/long |
|
P-value=0.061, OR=1.19 in the Norwegian samples; P-value=0.0......
P-value=0.061, OR=1.19 in the Norwegian samples; P-value=0.016, OR=1.36 in the Norwegian samples; P-value=0.98, OR=1 in the Norwegian males; meta-analysis P-value=0.06, OR=1.10 for S allele
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a trend for an association between the 5-HTTLPR S allele and......
a trend for an association between the 5-HTTLPR S allele and ADHD in the Norwegian sample, especially significant in females, but the meta-analysis refuted a strong effect
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Significant
|
Spencer, T. J., 2012 |
short/long |
long |
P-value=NS, X2=0.19
P-value=NS, X2=0.19
|
the gene frequencies of each of the gene polymorphisms asses......
the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups.
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Non-significant
|
Bidwell LC, 2011 |
short/long |
long |
FBAT-GEE: total ADHD, P-value=0.23 for short allele, P-value......
FBAT-GEE: total ADHD, P-value=0.23 for short allele, P-value=0.23 for long allele
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no significant associations were found
no significant associations were found
|
Non-significant
|