ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name 5HTTLPR
Type insertion/deletion
Location promoter
Length of Repeat Unit 44bp
Related Gene SLC6A4
No. of Study 21 (significant: 7; non-significant 14; trend: 0)

Variant related studies (count: 21)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Ilott NE, 2010 short/long QTDT AT P-value=0.57, X2=0.31, df=1, QTDT AW P-va...... QTDT AT P-value=0.57, X2=0.31, df=1, QTDT AW P-value=0.87, X2=0.03, df=1 at age 2; QTDT AT P value=0.87, X2=0.03, df=1, QTDT AW P-value=0.34, X2=0.91, df=1 at age 3 More... no significant association no significant association Non-significant
Wigg KG, 2006 short/long SA TDT P-value=0.456, X2=0.556; L...... SA TDT P-value=0.456, X2=0.556; LA TDT P-value=0.419, X2=0.654; LG TDT P-value=0.893, X2=0.018; LA+LG P-value=0.519 More... no evidence of biased transmission no evidence of biased transmission Non-significant
Kim SJ, 2005 short/long allelic TDT P-value=0.11 for ADHD pooled together, TDT P-val...... allelic TDT P-value=0.11 for ADHD pooled together, TDT P-value=0.036 for ADHD without ADHD NOS subtype; 5-HTTLPR allele frequencies: X2=2.60, df=1, P-value=0.11 compared to the previous reports [Kim et al., 2000, 2004a; Pae et al.,2003]; 5-HTTLPR allele frequencies: X2=2.70, df=2, P-value=0.60 among ADHD subtype groups excluding ADHD NOS subtype More... TDT revealed nominally significant LD between 5-HTTLPR and A...... TDT revealed nominally significant LD between 5-HTTLPR and ADHD; the frequencies of the alleles and genotypes did not differ significantly compared to the previous reports More... Significant
Guimaraes AP, 2007 short/long HRR P-value=0.53 (OR=1.1[0.82-1.45]) in total samples; HRR P...... HRR P-value=0.53 (OR=1.1[0.82-1.45]) in total samples; HRR P-value=0.14 (OR=1.25[0.92-1.71]) in boys samples. More... No evidences for biased transmission of alleles for this pol...... No evidences for biased transmission of alleles for this polymorphism to the ADHD probands were observed More... Non-significant
Gizer IR, 2009 short/long Meta-analysis model: Random: OR=1.17, 95% CI=1.02-1.33, P-va...... Meta-analysis model: Random: OR=1.17, 95% CI=1.02-1.33, P-value=0.01; Q-statistic: P-value=0.00003, I2=66 More... significant but modest association significant but modest association Significant
Beitchman JH, 2003 short/long Fisher's exact test P-value=0.041 Fisher's exact test P-value=0.041 there was a significant link between 5HTTLPR and ADHD, but n...... there was a significant link between 5HTTLPR and ADHD, but no significant association with aggression More... Significant
Li J, 2007 short/long Allelic TDT P-value=0.016 for ADHD, P-value=0.111 for ADHD-C...... Allelic TDT P-value=0.016 for ADHD, P-value=0.111 for ADHD-C, P-value=0.093 for ADHD-I More... preferential transmission of the S allele to ADHD offspring,...... preferential transmission of the S allele to ADHD offspring, but analyses of subtypes did not reach statistical significance More... Significant
Grevet EH, 2007 short/long chi-square test P-value=0.95, X2=0.69 for genotyp...... chi-square test P-value=0.95, X2=0.69 for genotype frequency, chi-square test P-value=0.34, X2=0.92 for allele frequency between ADHD and controls, chi-square test P-value=0.69, X2=1.47 for allele frequency between inattentives&combined and controls More... there were no significant alleles and genotypes differences ...... there were no significant alleles and genotypes differences in this case-control study More... Non-significant
Xu X, 2005(b) short/long allelic ETDT P-value=0.521, X2=0.412 in UK sample...... allelic ETDT P-value=0.521, X2=0.412 in UK samples; allelic ETDT P-value=0.497, X2=0.462 in Taiwanese samples; allelic ETDT P-value=0.943, X2=0.005 in combined samples; allelic HHRR P-value=0.546, X2=0.364 in UK samples; allelic HHRR P-value=0.530, X2=0.394 in Taiwanese samples; HHRR P-value=0.950, X2=0.004 in combined samples; allelic TRANSMIT P-value=0.689, X2=0.161 in UK samples; allelic TRANSMIT P-value=0.074, X2=3.192 in Taiwanese samples; allelic TRANSMIT P-value=0.696, X2=0.153 in combined samples More... there was no significant preferential transmission of the lo...... there was no significant preferential transmission of the long-allele in UK samples, Taiwanese samples and combined samples More... Non-significant
Nyman ES, 2007 short/long No available information. No available information. No evidence of association was seen. No evidence of association was seen. Non-significant
Langley K, 2003 short/long allelic ETDT P-value=0.37, X2=0.82 in the total s...... allelic ETDT P-value=0.37, X2=0.82 in the total sample; allelic ETDT P-value=0.82, X2=0.049, OR=1.04 in the case-control analysis More... there was no evidence of preferential transmission of the lo...... there was no evidence of preferential transmission of the long allele in the total sample and case-control differences were also not significant More... Non-significant
Manor I, 2001 short/long genotypic HRR P-value=0.11, likelihood ratio=4.45 in the ADH...... genotypic HRR P-value=0.11, likelihood ratio=4.45 in the ADHD group, genotypic HRR P-value=0.008, likelihood ratio=9.62 in the combined triads, genotypic HRR P-value=0.004, likelihood ratio=11.25 in the ADHD subjects excluding the inattentive group; allelic HRR P-value=0.31, likelihood ratio=1.03 in all ADHD traids, allelic HRR P-value=0.069, likelihood ratio=3.81 in the combined type; HRR P-value=0.108, likelihood ratio=4.45 in the case-control analysis More... there was a decreased homozygosity of the short/short genoty...... there was a decreased homozygosity of the short/short genotype in the ADHD group but not significant; a significant decrease in homozygosity of the short/short 5-HTTLPR genotype was observed in the ADHD group compared with the HRR control group in the combined traids and in ADHD subjects excluding the inattentive group; no significant differences in 5-HTTLPR allele frequency were observed in all ADHD triads and the ADHD combined type, and a deficit of the short 5-HTTLPR allele in the ADHD group was observed; statistical significance of genotype frequencies was not obtained using a case-control design More... Significant
Zoroglu SS, 2002 short/long Fisher¡¯s exact test, allelic P-value=0.289; Pearson P-value...... Fisher¡¯s exact test, allelic P-value=0.289; Pearson P-value=0.018, X2=8.003, d.f.=2 of S/S genotype More... S and L alleles of 5-HTTLPR were similar between the control...... S and L alleles of 5-HTTLPR were similar between the controls and patients; the 5-HTTLPR S/S genotype was represented significantly less in the patients than in the controls More... Significant
Zhao AL, 2005 short/long allelic and genotypic chi-square test P-value>0.05 allelic and genotypic chi-square test P-value>0.05 no significant associations were seen between the frequencie...... no significant associations were seen between the frequencies of any genotype or allele of 5-HTTLPR and ADHD More... Non-significant
Heiser P, 2007 short/long allelic PDT P-value=0.12 allelic PDT P-value=0.12 showed no statistically significant preferential transmissio...... showed no statistically significant preferential transmission of any allele More... Non-significant
Banerjee E, 2006 short/long X2=0.37, df=1; P-value=0.543; HHRR X2=...... X2=0.37, df=1; P-value=0.543; HHRR X2=0, RR=1.00; TDT X2=0, OR=1.00 More... revealed no significant association revealed no significant association Non-significant
Bidwell LC, 2011 short/long long FBAT-GEE: total ADHD, P-value=0.23 for short allele, P-value...... FBAT-GEE: total ADHD, P-value=0.23 for short allele, P-value=0.23 for long allele More... no significant associations were found no significant associations were found Non-significant
Landaas ET, 2010 short/long P-value=0.061, OR=1.19 in the Norwegian samples; P-value=0.0...... P-value=0.061, OR=1.19 in the Norwegian samples; P-value=0.016, OR=1.36 in the Norwegian samples; P-value=0.98, OR=1 in the Norwegian males; meta-analysis P-value=0.06, OR=1.10 for S allele More... a trend for an association between the 5-HTTLPR S allele and...... a trend for an association between the 5-HTTLPR S allele and ADHD in the Norwegian sample, especially significant in females, but the meta-analysis refuted a strong effect More... Significant
Kent L, 2002 short/long long TDT P-value>0.05 TDT P-value>0.05 No significant evidence was found for biased transmission No significant evidence was found for biased transmission Non-significant
Spencer, T. J., 2012 short/long long P-value=NS, X2=0.19 P-value=NS, X2=0.19 the gene frequencies of each of the gene polymorphisms asses...... the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups. More... Non-significant
Xu X, 2008(a) short/long TDT P-value=0.27, X2=1.21, OR=1.07, for L allele;...... TDT P-value=0.27, X2=1.21, OR=1.07, for L allele; TDT P-value=0.27, X2=1.21, OR=0.93, for S allele More... were not significantly associated with ADHD were not significantly associated with ADHD Non-significant