Study Report

Basic Info
Reference |
Zhao AL, 200516040360
|
Citation |
Zhao A. L., Su L. Y., Zhang Y. H., Tang B. S., Luo X. R., Huang C. X. and Su Q. R. (2005) "Association analysis of serotonin transporter promoter gene polymorphism with ADHD and related symptomatology." Int J Neurosci, 115(8): 1183-91.
|
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
139 patients and 115 controls |
Predominant Ethnicity |
Mongoloid |
Population |
China |
Gender |
120 male and 19 female patients, 94 male and 21 female controls |
Age Group |
Children/Adolescents
:
case: 4-14 (mean age: 9.1, SD=2.4) years; control: 4-15 (mean age: 8.8, SD=2.8) years
|

Detail Info
Summary |
Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop attention deficit hyperactivity disorder. Several investigations have reported associations between ADHD and serotonin transporter promoter polymorphisms, but the results have been inconsistent. The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele. |
Total Sample |
One-hundred and thirty-nine patients with ADHD and 115 healthy volunteers were included in the study. There were 120 male and 19 female patients with their ages ranging from 4-14 years and 94 male and 21 female controls with their ages ranging from 4-15 years. Both patients and controls were Chinese Han population, and all were from the same area in Hunan, China. |
Sample Collection |
Patients with ADHD were recruited from the Department of Psychiatry, The Second Xiangya Hospital, Central South University. |
Diagnosis Description |
The diagnosis of ADHD was made on the basis of DSM-IV criteria either with or without comorbidity. |
Technique |
Using the PCR technique, polymorphism of 5-HTTLPR was analyzed in the DNAs obtained from leUnited Kingdomocytes of the patients and healthy controls. |
Analysis Method |
Allele frequencies were estimated by counting alleles and calculating sample proportions. Comparisons of genotype frequencies and allele frequencies were made using the chi-square test. |
Result Description |
The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele. |

Other variant reported by this study (count: 1)
Variant Name |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
5HTTLPR |
short/long |
|
allelic and genotypic chi-square test P-value>0.05
allelic and genotypic chi-square test P-value>0.05
|
no significant associations were seen between the frequencies of any genotype or allele of 5-HTTLPR and ADHD |
Non-significant
|

Genes reported by this study (count: 1)
Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
SLC6A4 |
no significant associations were seen between 5-HTTLPR and A......
no significant associations were seen between 5-HTTLPR and ADHD
More...
|
Non-significant
|