ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Zhao AL, 200516040360
Citation	Zhao A. L., Su L. Y., Zhang Y. H., Tang B. S., Luo X. R., Huang C. X. and Su Q. R. (2005) "Association analysis of serotonin transporter promoter gene polymorphism with ADHD and related symptomatology." Int J Neurosci, 115(8): 1183-91.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	139 patients and 115 controls
Predominant Ethnicity	Mongoloid
Population	China
Gender	120 male and 19 female patients, 94 male and 21 female controls
Age Group	Children/Adolescents : case: 4-14 (mean age: 9.1, SD=2.4) years; control: 4-15 (mean age: 8.8, SD=2.8) years

Detail Info

Summary	Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop attention deficit hyperactivity disorder. Several investigations have reported associations between ADHD and serotonin transporter promoter polymorphisms, but the results have been inconsistent. The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele.
Total Sample	One-hundred and thirty-nine patients with ADHD and 115 healthy volunteers were included in the study. There were 120 male and 19 female patients with their ages ranging from 4-14 years and 94 male and 21 female controls with their ages ranging from 4-15 years. Both patients and controls were Chinese Han population, and all were from the same area in Hunan, China.
Sample Collection	Patients with ADHD were recruited from the Department of Psychiatry, The Second Xiangya Hospital, Central South University.
Diagnosis Description	The diagnosis of ADHD was made on the basis of DSM-IV criteria either with or without comorbidity.
Technique	Using the PCR technique, polymorphism of 5-HTTLPR was analyzed in the DNAs obtained from leUnited Kingdomocytes of the patients and healthy controls.
Analysis Method	Allele frequencies were estimated by counting alleles and calculating sample proportions. Comparisons of genotype frequencies and allele frequencies were made using the chi-square test.
Result Description	The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele.

Other variant reported by this study (count: 1)

Genes reported by this study (count: 1)