ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name SLC6A4_intron2_VNTR
Type VNTR
Location intron 2
Length of Repeat Unit 17bp
Related Gene SLC6A4
No. of Study 14 (significant: 4; non-significant 10; trend: 0)

Variant related studies (count: 14)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Langley K, 2003 ETDT P-value=0.619, X2=0.248 for allele 10, ETDT ...... ETDT P-value=0.619, X2=0.248 for allele 10, ETDT P-value=0.763, X2=0.091 for allele 12, TRANSMIT P-value=0.516 in the total sample; allelic P-value=0.14, X2=2.14, OR=0.992 in the case-control analysis More... no significant preferential transmission was found in the to...... no significant preferential transmission was found in the total sample, and no significant differences were found when clumped alleles 9 and 10 for the case-control analysis More... Non-significant
Kim SJ, 2005 allelic TDT P-value=0.72 for ADHD pooled together, TDT P-val...... allelic TDT P-value=0.72 for ADHD pooled together, TDT P-value=0.2 for ADHD without ADHD NOS subtype; compared to the previous reports from Korean populations [Kim et al., 2000, 2004a; Pae et al.,2003], Intron 2 VNTR allele frequencies: X2=0.001, df=1, P-value=0.97; Intron 2 VNTR allele frequencies: X2=0.64, df=2, P-value=0.73 among ADHD subtype groups excluding ADHD NOS subtype More... no significant association was detected in the family-based ...... no significant association was detected in the family-based study and no significant difference compared to the previous study More... Non-significant
Kent L, 2002 9, 10, 12 repeat 10 repeat TDT P-value>0.05 TDT P-value>0.05 No significant evidence was found for biased transmission No significant evidence was found for biased transmission Non-significant
Beitchman JH, 2003 P-value=0.015, X2=5.959 for 10R allele P-value=0.015, X2=5.959 for 10R allele 10R allele was significantly less frequent among cases than ...... 10R allele was significantly less frequent among cases than controls, associated with aggressive behavior in this sample More... Significant
Xu X, 2005(b) allelic ETDT P-value=0.497, X2=1.399 in UK sample...... allelic ETDT P-value=0.497, X2=1.399 in UK samples; allelic ETDT P-value=0.440, X2=1.644 in Taiwanese samples; allelic ETDT P-value=0.355, X2=2.071 in combined samples; allelic HHRR P-value=0.517, X2=1.318 in UK samples; allelic HHRR P-value=0.446, X2=1.615 in Taiwanese samples; HHRR P-value=0.381, X2=1.929 in combined samples; allelic TRANSMIT P-value=0.850, X2=0.324 in UK samples; allelic TRANSMIT P-value=0.706, X2=0.692 in Taiwanese samples; allelic TRANSMIT P-value=0.813, X2=0.413 in combined samples More... there was no significant preferential transmission in UK sam...... there was no significant preferential transmission in UK samples, Taiwanese samples and combined samples More... Non-significant
Li J, 2007 Allelic TDT P-value=0.834 for ADHD, P-value=0.728 for ADHD-C...... Allelic TDT P-value=0.834 for ADHD, P-value=0.728 for ADHD-C, P-value=0.683 for ADHD-I More... No significant biased transmission of any allele was observe...... No significant biased transmission of any allele was observed for ADHD or subtypes of ADHD. More... Non-significant
Oades RD, 2008 P-value= 0.050 for cognitive impulsivity P-value= 0.050 for cognitive impulsivity nominally significant association nominally significant association Significant
Spencer, T. J., 2012 12R P-value=NS, X2=0.11 P-value=NS, X2=0.11 the gene frequencies of each of the gene polymorphisms asses...... the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups. More... Non-significant
Gizer IR, 2009 10R Meta-analysis model: Fixed: OR=1.01, 95% CI=0.92-1.10, P-val...... Meta-analysis model: Fixed: OR=1.01, 95% CI=0.92-1.10, P-value=0.428; Q-statistic: P-value=0.85, I2=0 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Heiser P, 2007 340/357/391 allelic PDT P-value=0.45 allelic PDT P-value=0.45 showed no statistically significant preferential transmissio...... showed no statistically significant preferential transmission of any allele More... Non-significant
Forero DA, 2009 Not significant for the total samples. Not significant for the total samples. Non-significant
Zoroglu SS, 2002 Fisher¡¯s exact test, allelic P-value=0.288; Pearson P-value...... Fisher¡¯s exact test, allelic P-value=0.288; Pearson P-value=0.001, X2=13.27, d.f.=2 of STin2.12/12 genotype More... there was no significant difference between the frequencies ...... there was no significant difference between the frequencies of the VNTR STin2.10 and STin2.12 alleles; the VNTR STin2.12/12 genotype was significantly less in the patients than the controls More... Significant
Xu X, 2008(a) 9/10/12 allele TDT P-value=1.00, X2=0.00, OR=1.00, for 9 allele;...... TDT P-value=1.00, X2=0.00, OR=1.00, for 9 allele; TDT P-value=0.74, X2=0.11, OR=1.02, for 10 allele; TDT P-value=0.74, X2=0.11, OR=0.98, for 12 allele More... were not significantly associated with ADHD were not significantly associated with ADHD Non-significant
Banerjee E, 2006 A10/A12 X2=1.137, df=1; P-value=0.286; HHRR P-value=0.027...... X2=1.137, df=1; P-value=0.286; HHRR P-value=0.027, X2=4.92, RR=1.47; TDT P-value=0.008, X2=7.00, OR=3.00; paternal transmission HHRR P-value=0.437, X2=0.604, RR=1.24, TDT P-value=0.405, X2=0.692, OR=1.60; maternal transmission HHRR P-value=0.011, X2=6.532, RR=2.00, TDT P-value=0.005, X2=8.066, OR=6.50 More... A12 allele is statistically significant in HHRR and TDT anal...... A12 allele is statistically significant in HHRR and TDT analysis, and in maternal inheritance More... Significant