ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP16
Previous Symbol	C8orf57
Symbol Alias	MT3-MMP, DKFZp761D112
Approved Name	matrix metallopeptidase 16 (membrane-inserted)
Previous Name	matrix metalloproteinase 16 (membrane-inserted), "chromosome 8 open reading frame 57"
Location	8q21
Position	chr8:89044237-89340254, -
External Links	HGNC: 7162 Entrez Gene: 4325 Ensembl: ENSG00000156103 UCSC: uc003yeb.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_54	chr8:89227035-90419753 (NCBI Build 36.1 (hg18))	1139681	8q21.3	Gain	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006508	proteolysis	Biological Process		102
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7559440]	220
GO:0008270	zinc ion binding	Molecular Function		323
GO:0008047	enzyme activator activity	Molecular Function	TAS[7559440]	7
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0009986	cell surface	Cellular Component		70
GO:0030574	collagen catabolic process	Biological Process		10
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005886	plasma membrane	Cellular Component		772
GO:0005796	Golgi lumen	Cellular Component		12
GO:0043085	positive regulation of catalytic activity	Biological Process	TAS[7559440]	7

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MMP16 (count: 19)

Gene Symbol	Pathway Count	Pathway List
MMP11	9	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; Golgi lumen;
MMP1	8	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP10	8	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP13	8	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP24	8	proteolysis; integral to plasma membrane; zinc ion binding; enzyme activator activity; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding; positive regulation of catalytic activity;
MMP3	8	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP8	8	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
ADAM8	7	proteolysis; integral to plasma membrane; zinc ion binding; cell surface; metalloendopeptidase activity; calcium ion binding; plasma membrane;
MMP7	7	proteolysis; zinc ion binding; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix;
ADAMTS2	6	proteolysis; zinc ion binding; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix;
FURIN	6	proteolysis; extracellular matrix disassembly; cell surface; extracellular matrix organization; plasma membrane; Golgi lumen;
MMP27	6	proteolysis; zinc ion binding; collagen catabolic process; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
ADAMTS7	5	proteolysis; zinc ion binding; cell surface; metalloendopeptidase activity; proteinaceous extracellular matrix;
CTSG	5	proteolysis; extracellular matrix disassembly; cell surface; extracellular matrix organization; plasma membrane;
MEP1B	5	proteolysis; integral to plasma membrane; zinc ion binding; metalloendopeptidase activity; plasma membrane;
MMP12	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP20	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
TLL1	5	proteolysis; zinc ion binding; extracellular matrix organization; metalloendopeptidase activity; calcium ion binding;
ADAM17	5	integral to plasma membrane; zinc ion binding; cell surface; metalloendopeptidase activity; plasma membrane;

Genes shared at least 2 KEGG pathways with MMP16 (count: 0)

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Region: chr8:89044237..89340254 View in gBrowse