ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MMP12
Symbol Alias	HME
Approved Name	matrix metallopeptidase 12 (macrophage elastase)
Previous Name	"matrix metalloproteinase 12 (macrophage elastase)"
Location	11q22.3
Position	chr11:102733467-102745764, -1
External Links	HGNC: 7158 Entrez Gene: 4321 UCSC: uc001phk.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006508	proteolysis	biological process	IEA	123
GO:0035313	wound healing, spreading of epidermal cells	biological process	IDA[15802269]	2
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0004222	metalloendopeptidase activity	molecular function	TAS[8226919]	36
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	51
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0004175	endopeptidase activity	molecular function	TAS[8226919]	5
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	biological process	IDA[15802269]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MMP12 (count: 11)

Gene Symbol	Pathway Count	Pathway List
MMP10	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP1	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP11	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP8	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP24	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP25	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP20	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP27	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP13	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP16	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP3	5	proteolysis; zinc ion binding; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;

Genes shared at least 2 KEGG pathways with MMP12 (count: 0)

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Region: chr11:102733467..102745764 View in gBrowse