ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MMP24
Symbol Alias	MT5-MMP
Approved Name	matrix metallopeptidase 24 (membrane-inserted)
Previous Name	matrix metalloproteinase 24 (membrane-inserted)
Name Alias	membrane-type 5 matrix metalloproteinase
Location	20q11.2
Position	chr20:33814457-33864804, +
External Links	HGNC: 7172 Entrez Gene: 10893 Ensembl: ENSG00000125966 UCSC: uc002xbu.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 8)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1555322	Chr20:33849179(Fwd)	intron_variant; nc_transcript_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs1205411	Chr20:33857242(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2425037	Chr20:33856429(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2425032	Chr20:33855454(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2425027	Chr20:33849390(Fwd)	intron_variant; nc_transcript_variant
rs2247828	Chr20:33839939(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2425022	Chr20:33831187(Fwd)	intron_variant; nc_transcript_variant
rs2425021	Chr20:33829778(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008270	zinc ion binding	Molecular Function		323
GO:0043085	positive regulation of catalytic activity	Biological Process	TAS[10363975]	7
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005887	integral to plasma membrane	Cellular Component	TAS[10363975]	220
GO:0006508	proteolysis	Biological Process		102
GO:0008047	enzyme activator activity	Molecular Function	TAS[10363975]	7

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MMP24 (count: 11)

Gene Symbol	Pathway Count	Pathway List
MMP16	8	zinc ion binding; positive regulation of catalytic activity; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; integral to plasma membrane; proteolysis; enzyme activator activity;
ADAM8	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; integral to plasma membrane; proteolysis;
MMP1	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP10	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP11	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP12	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP13	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP20	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP27	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP3	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;
MMP8	5	zinc ion binding; metalloendopeptidase activity; calcium ion binding; proteinaceous extracellular matrix; proteolysis;

Genes shared at least 2 KEGG pathways with MMP24 (count: 0)

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Region: chr20:33814457..33864804 View in gBrowse