ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0004222
Name metalloendopeptidase activity
Type molecular function
No. of Genes in ADHDgene  36
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 36)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
NLN neurolysin (metallopeptidase M3 family) 5q12.3 1(1/0/0) IEA
TLL2 tolloid-like 2 10q23-q24 1(0/0/1) IEA
MMP24 matrix metallopeptidase 24 (membrane-inserted) 20q11.2 1(0/0/1) IEA
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1) IEA

Genes from other sources Help (count: 32)

Approved Symbol Approved Name Source Evidence[PMID]
ADAM7 ADAM metallopeptidase domain 7 Mapped by LD-proxy IEA
MMP25 matrix metallopeptidase 25 Mapped by significant region IEA
RCE1 Ras converting CAAX endopeptidase 1 Mapped by significant region TAS[10085068]
MMP11 matrix metallopeptidase 11 (stromelysin 3) Mapped by CNV IEA
C9orf3 chromosome 9 open reading frame 3 Mapped by significant region IEA
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 Mapped by significant region IEA
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 Mapped by Literature SNP; Mapped by CNV IEA
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region IEA
ADAM8 ADAM metallopeptidase domain 8 Mapped by LD-proxy; Mapped by CNV IEA
TRHDE thyrotropin-releasing hormone degrading enzyme Mapped by LD-proxy IEA
ASTL astacin-like metallo-endopeptidase (M12 family) Mapped by LD-proxy IDA[15087446]
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 Mapped by significant region IEA
MMP12 matrix metallopeptidase 12 (macrophage elastase) Mapped by significant region TAS[8226919]
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) Mapped by significant region IDA[11549317]
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) Mapped by significant region IEA
ADAM19 ADAM metallopeptidase domain 19 Mapped by significant region IEA
MMP16 matrix metallopeptidase 16 (membrane-inserted) Mapped by CNV IEA
MMP13 matrix metallopeptidase 13 (collagenase 3) Mapped by significant region IEA
MMP10 matrix metallopeptidase 10 (stromelysin 2) Mapped by significant region IEA
MMP1 matrix metallopeptidase 1 (interstitial collagenase) Mapped by significant region IDA[9920899]
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 Mapped by LD-proxy IEA
THOP1 thimet oligopeptidase 1 Mapped by LD-proxy IEA
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 Mapped by CNV; Mapped by significant region IEA
ADAM17 ADAM metallopeptidase domain 17 Mapped by significant region IDA[9920899]; IMP[9034191]; TAS
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 Mapped by significant region IEA
MMP20 matrix metallopeptidase 20 Mapped by significant region IEA
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 Mapped by significant region IEA
MMP27 matrix metallopeptidase 27 Mapped by significant region IEA
ADAM33 ADAM metallopeptidase domain 33 Mapped by CNV NAS[11814695]
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) Mapped by significant region IEA
TLL1 tolloid-like 1 Mapped by Literature SNP IEA
MEP1B meprin A, beta Mapped by significant region IEA