ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TLL2
Approved Name	tolloid-like 2
Location	10q23-q24
Position	chr10:98124363-98273683, -
External Links	HGNC: 11844 Entrez Gene: 7093 Ensembl: ENSG00000095587 UCSC: uc001kml.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs10786284	Chr10:98135505(Fwd)	intron_variant; upstream_gene_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs11188739	Chr10:98135631(Fwd)	intron_variant; upstream_gene_variant
rs12268514	Chr10:98134903(Fwd)	intron_variant; nc_transcript_variant
rs3827865	Chr10:98138568(Fwd)	intron_variant; upstream_gene_variant
rs7900503	Chr10:98136718(Fwd)	intron_variant; upstream_gene_variant
rs3762096	Chr10:98136250(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	No. of Genes in ADHDgene
GO:0004222	metalloendopeptidase activity	Molecular Function	33
GO:0006508	proteolysis	Biological Process	102
GO:0007275	multicellular organismal development	Biological Process	71
GO:0005509	calcium ion binding	Molecular Function	124
GO:0005576	extracellular region	Cellular Component	240
GO:0008270	zinc ion binding	Molecular Function	323
GO:0030154	cell differentiation	Biological Process	51

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TLL2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
MMP11	6	metalloendopeptidase activity; proteolysis; multicellular organismal development; calcium ion binding; extracellular region; zinc ion binding;
TLL1	6	metalloendopeptidase activity; proteolysis; calcium ion binding; extracellular region; zinc ion binding; cell differentiation;
MMP1	5	metalloendopeptidase activity; proteolysis; calcium ion binding; extracellular region; zinc ion binding;
MMP10	5	metalloendopeptidase activity; proteolysis; calcium ion binding; extracellular region; zinc ion binding;
MMP13	5	metalloendopeptidase activity; proteolysis; calcium ion binding; extracellular region; zinc ion binding;
MMP3	5	metalloendopeptidase activity; proteolysis; calcium ion binding; extracellular region; zinc ion binding;
MMP8	5	metalloendopeptidase activity; proteolysis; calcium ion binding; extracellular region; zinc ion binding;

Genes shared at least 2 KEGG pathways with TLL2 (count: 0)

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Region: chr10:98124363..98273683 View in gBrowse