ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MMP11
Previous Symbol	STMY3
Approved Name	matrix metallopeptidase 11 (stromelysin 3)
Previous Name	matrix metalloproteinase 11 (stromelysin 3)
Location	22q11.23
Position	chr22:24110413-24126503, +
External Links	HGNC: 7157 Entrez Gene: 4320 Ensembl: ENSG00000099953 UCSC: uc002zxx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_37	chr22:22020325-23326630 (NCBI Build 36.1 (hg18))	1306306	22q11.23	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007275	multicellular organismal development	Biological Process	TAS[7746327]	71
GO:0006508	proteolysis	Biological Process		102
GO:0030574	collagen catabolic process	Biological Process		10
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005796	Golgi lumen	Cellular Component		12
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005576	extracellular region	Cellular Component		240
GO:0005509	calcium ion binding	Molecular Function		124

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MMP11 (count: 14)

Gene Symbol	Pathway Count	Pathway List
MMP1	9	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; calcium ion binding;
MMP10	9	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; calcium ion binding;
MMP13	9	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; calcium ion binding;
MMP16	9	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; Golgi lumen; proteinaceous extracellular matrix; calcium ion binding;
MMP3	9	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; calcium ion binding;
MMP8	9	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; calcium ion binding;
MMP7	8	extracellular matrix disassembly; zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region;
ADAMTS2	7	zinc ion binding; proteolysis; collagen catabolic process; extracellular matrix organization; metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region;
MMP27	6	zinc ion binding; proteolysis; collagen catabolic process; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
TLL1	6	zinc ion binding; proteolysis; extracellular matrix organization; metalloendopeptidase activity; extracellular region; calcium ion binding;
TLL2	6	zinc ion binding; multicellular organismal development; proteolysis; metalloendopeptidase activity; extracellular region; calcium ion binding;
MMP12	5	zinc ion binding; proteolysis; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP20	5	zinc ion binding; proteolysis; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;
MMP24	5	zinc ion binding; proteolysis; metalloendopeptidase activity; proteinaceous extracellular matrix; calcium ion binding;

Genes shared at least 2 KEGG pathways with MMP11 (count: 0)

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Region: chr22:24110413..24126503 View in gBrowse