ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADAMTS2
Symbol Alias	ADAMTS-3, hPCPNI, PCINP, ADAM-TS2, NPI
Approved Name	ADAM metallopeptidase with thrombospondin type 1 motif, 2
Previous Name	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
Name Alias	procollagen I N-proteinase, "procollagen N-endopeptidase"
Location	5q23-q24
Position	chr5:178537852-178772431, -
External Links	HGNC: 218 Entrez Gene: 9509 Ensembl: ENSG00000087116 UCSC: uc003mjw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs180045	Chr5:178639086(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_14	chr5:178157153-180497731 (NCBI36 / hg18)	2340579	5q35.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005576	extracellular region	Cellular Component		240
GO:0007283	spermatogenesis	Biological Process		35
GO:0006508	proteolysis	Biological Process		102
GO:0008270	zinc ion binding	Molecular Function		323
GO:0008237	metallopeptidase activity	Molecular Function	TAS[10417273]	13
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0016485	protein processing	Biological Process		8
GO:0030324	lung development	Biological Process		12
GO:0030199	collagen fibril organization	Biological Process		5
GO:0043588	skin development	Biological Process		7
GO:0030574	collagen catabolic process	Biological Process		10

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ADAMTS2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
MMP1	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP10	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP11	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP13	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP3	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP7	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP8	7	metalloendopeptidase activity; proteinaceous extracellular matrix; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
MMP16	6	metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding; extracellular matrix organization; collagen catabolic process;
ADAMTS7	5	metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding; metallopeptidase activity;
ADAMTS8	5	metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding; metallopeptidase activity;
MMP27	5	metalloendopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding; collagen catabolic process;
TLL1	5	metalloendopeptidase activity; extracellular region; proteolysis; zinc ion binding; extracellular matrix organization;

Genes shared at least 2 KEGG pathways with ADAMTS2 (count: 0)

View in gBrowse

Region: chr5:178537852..178772431 View in gBrowse