ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ADAMTS8
Symbol Alias	METH2, FLJ41712, ADAM-TS8
Approved Name	ADAM metallopeptidase with thrombospondin type 1 motif, 8
Previous Name	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
Location	11q25
Position	chr11:130274818-130298888, -
External Links	HGNC: 224 Entrez Gene: 11095 Ensembl: ENSG00000134917 UCSC: uc001qgg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0005178	integrin binding	Molecular Function	TAS[10438512]	15
GO:0008201	heparin binding	Molecular Function		26
GO:0008237	metallopeptidase activity	Molecular Function	TAS[10438512]	13
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0006508	proteolysis	Biological Process		102
GO:0009673	low affinity phosphate transmembrane transporter activity	Molecular Function	TAS[10610729]	1
GO:0031012	extracellular matrix	Cellular Component		28
GO:0008270	zinc ion binding	Molecular Function		323
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS[10438512]	59

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ADAMTS8 (count: 2)

Gene Symbol	Pathway Count	Pathway List
ADAMTS2	5	metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding;
ADAMTS7	5	metalloendopeptidase activity; metallopeptidase activity; proteinaceous extracellular matrix; proteolysis; zinc ion binding;

Genes shared at least 2 KEGG pathways with ADAMTS8 (count: 0)

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Region: chr11:130274818..130298888 View in gBrowse