ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ASTL
Symbol Alias	ovastacin
Approved Name	astacin-like metallo-endopeptidase (M12 family)
Previous Name	astacin-like metalloendopeptidase (M12 family)
Location	2q11.1
Position	chr2:96789589-96804175, -
External Links	HGNC: 31704 Entrez Gene: 431705 Ensembl: ENSG00000188886 UCSC: uc010yui.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 8)

rs_ID	Location	Functional Annotation
rs893173	Chr2:96789787(Fwd)	synonymous_variant
rs2692894	Chr2:96784934(Fwd)	downstream_gene_variant; upstream_gene_variant
rs2969491	Chr2:96794982(Fwd)	downstream_gene_variant; intron_variant
rs2969490	Chr2:96803904(Fwd)	intron_variant; upstream_gene_variant
rs1657502	Chr2:96795608(Fwd)	downstream_gene_variant; missense_variant
rs1168965	Chr2:96787899(Fwd)	downstream_gene_variant
rs749459	Chr2:96795714(Fwd)	downstream_gene_variant; synonymous_variant
rs749457	Chr2:96795944(Fwd)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:2000360	negative regulation of binding of sperm to zona pellucida	Biological Process		2
GO:0070002	glutamic-type peptidase activity	Molecular Function		1
GO:0070001	aspartic-type peptidase activity	Molecular Function		1
GO:0060473	cortical granule	Cellular Component		1
GO:0060468	prevention of polyspermy	Biological Process		2
GO:0004222	metalloendopeptidase activity	Molecular Function	IDA[15087446]	33
GO:0005737	cytoplasm	Cellular Component		690
GO:0010954	positive regulation of protein processing	Biological Process		2
GO:0030133	transport vesicle	Cellular Component		4
GO:0008270	zinc ion binding	Molecular Function		323
GO:0009566	fertilization	Biological Process		3
GO:0007155	cell adhesion	Biological Process		86
GO:0008233	peptidase activity	Molecular Function	IDA[15087446]	15
GO:0005886	plasma membrane	Cellular Component		772
GO:0006508	proteolysis	Biological Process	IDA[15087446]	102

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ASTL (count: 2)

Gene Symbol	Pathway Count	Pathway List
ADAM8	6	metalloendopeptidase activity; cytoplasm; positive regulation of protein processing; zinc ion binding; plasma membrane; proteolysis;
ADAM17	5	metalloendopeptidase activity; cytoplasm; zinc ion binding; cell adhesion; plasma membrane;

Genes shared at least 2 KEGG pathways with ASTL (count: 0)

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Region: chr2:96789589..96804175 View in gBrowse