ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TRHDE
Symbol Alias	PGPEP2, TRH-DE, PAP-II
Approved Name	thyrotropin-releasing hormone degrading enzyme
Name Alias	pyroglutamyl-peptidase II
Location	12q15-q21
Position	chr12:72666463-73059422, +
External Links	HGNC: 30748 Entrez Gene: 29953 Ensembl: ENSG00000072657 UCSC: uc001sxa.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation
rs4760822	Chr12:72479611(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs3858589	Chr12:72499323(Fwd)	intron_variant; nc_transcript_variant
rs11614604	Chr12:72503687(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006508	proteolysis	Biological Process		102
GO:0005887	integral to plasma membrane	Cellular Component	TAS[10491199]	220
GO:0004222	metalloendopeptidase activity	Molecular Function		33
GO:0004177	aminopeptidase activity	Molecular Function		6
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007267	cell-cell signaling	Biological Process	TAS[10491199]	38
GO:0007165	signal transduction	Biological Process	TAS[10491199]	171

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TRHDE (count: 0)

Genes shared at least 2 KEGG pathways with TRHDE (count: 0)

View in gBrowse

Region: chr12:72666463..73059422 View in gBrowse