ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	F10
Approved Name	coagulation factor X
Location	13q34
Position	chr13:113777113-113803843, +
External Links	HGNC: 3528 Entrez Gene: 2159 Ensembl: ENSG00000126218 UCSC: uc001vsx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_155	chr13:112336427-112835822 (NCBI Build 35 (hg17))	499396	13q34	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031233	intrinsic to external side of plasma membrane	Cellular Component	IC[17469850]	1
GO:0030335	positive regulation of cell migration	Biological Process	TAS[18612547]	29
GO:0017187	peptidyl-glutamic acid carboxylation	Biological Process		4
GO:0007598	blood coagulation, extrinsic pathway	Biological Process		2
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process	IDA[18612547]	17
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0043687	post-translational protein modification	Biological Process		37
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0005796	Golgi lumen	Cellular Component		12
GO:0005543	phospholipid binding	Molecular Function	IDA[17469850]	61
GO:0005576	extracellular region	Cellular Component	NAS[14718574]	240
GO:0007596	blood coagulation	Biological Process	IC[17469850]	83
GO:0007597	blood coagulation, intrinsic pathway	Biological Process		4
GO:0005886	plasma membrane	Cellular Component		772
GO:0006508	proteolysis	Biological Process		102
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005515	protein binding	Molecular Function	IPI[6323392]	910
GO:0004252	serine-type endopeptidase activity	Molecular Function	IDA[17469850]	29

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04610	Complement and coagulation cascades	12	The complement system is a proteolytic cascade in blood plas...... The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. More...

Genes shared at least 5 GO terms with F10 (count: 11)

Gene Symbol	Pathway Count	Pathway List
F7	14	positive regulation of cell migration; peptidyl-glutamic acid carboxylation; blood coagulation, extrinsic pathway; positive regulation of protein kinase B signaling cascade; cellular protein metabolic process; post-translational protein modification; endoplasmic reticulum lumen; Golgi lumen; extracellular region; blood coagulation; plasma membrane; proteolysis; calcium ion binding; serine-type endopeptidase activity;
FURIN	7	peptidyl-glutamic acid carboxylation; cellular protein metabolic process; post-translational protein modification; Golgi lumen; plasma membrane; proteolysis; serine-type endopeptidase activity;
INS	6	positive regulation of cell migration; positive regulation of protein kinase B signaling cascade; endoplasmic reticulum lumen; Golgi lumen; extracellular region; protein binding;
APOA1	6	endoplasmic reticulum lumen; phospholipid binding; extracellular region; blood coagulation; plasma membrane; protein binding;
ADAM8	5	positive regulation of protein kinase B signaling cascade; plasma membrane; proteolysis; calcium ion binding; protein binding;
CANX	5	cellular protein metabolic process; post-translational protein modification; endoplasmic reticulum lumen; calcium ion binding; protein binding;
EDEM2	5	cellular protein metabolic process; post-translational protein modification; endoplasmic reticulum lumen; extracellular region; calcium ion binding;
SNCA	5	phospholipid binding; extracellular region; plasma membrane; calcium ion binding; protein binding;
MASP2	5	extracellular region; proteolysis; calcium ion binding; protein binding; serine-type endopeptidase activity;
PRSS8	5	extracellular region; plasma membrane; proteolysis; protein binding; serine-type endopeptidase activity;
PRCP	5	blood coagulation; blood coagulation, intrinsic pathway; plasma membrane; proteolysis; protein binding;

Genes shared at least 2 KEGG pathways with F10 (count: 0)

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Region: chr13:113777113..113803843 View in gBrowse