ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	F10
Approved Name	coagulation factor X
Location	13q34
Position	chr13:113777128-113803843, 1
External Links	HGNC: 3528 Entrez Gene: 2159 Ensembl: ENSG00000126218 UCSC: uc001vsx.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_155	chr13:112336427-112835822 (NCBI Build 35 (hg17))	499396	13q34	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0017187	peptidyl-glutamic acid carboxylation	biological process	TAS	4
GO:0044267	cellular protein metabolic process	biological process	TAS	78
GO:0007597	blood coagulation, intrinsic pathway	biological process	TAS	4
GO:0030335	positive regulation of cell migration	biological process	TAS[18612547]	28
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS	35
GO:0005796	Golgi lumen	cellular component	TAS	14
GO:0031233	intrinsic to external side of plasma membrane	cellular component	IC[17469850]	1
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0004252	serine-type endopeptidase activity	molecular function	IDA[17469850]; TAS	40
GO:0005515	protein binding	molecular function	IPI[6323392]	1015
GO:0007596	blood coagulation	biological process	IC[17469850]; TAS	85
GO:0006508	proteolysis	biological process	TAS	123
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0007598	blood coagulation, extrinsic pathway	biological process	TAS	2
GO:0005543	phospholipid binding	molecular function	IDA[17469850]	66
GO:0051897	positive regulation of protein kinase B signaling cascade	biological process	IDA[18612547]	17
GO:0005576	extracellular region	cellular component	NAS[14718574]; TAS	267
GO:0043687	post-translational protein modification	biological process	TAS	42

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04610	Complement and coagulation cascades	11

Genes shared at least 5 GO terms with F10 (count: 10)

Gene Symbol	Pathway Count	Pathway List
F7	14	peptidyl-glutamic acid carboxylation; cellular protein metabolic process; positive regulation of cell migration; endoplasmic reticulum lumen; Golgi lumen; plasma membrane; serine-type endopeptidase activity; blood coagulation; proteolysis; calcium ion binding; blood coagulation, extrinsic pathway; positive regulation of protein kinase B signaling cascade; extracellular region; post-translational protein modification;
FURIN	7	peptidyl-glutamic acid carboxylation; cellular protein metabolic process; Golgi lumen; plasma membrane; serine-type endopeptidase activity; proteolysis; post-translational protein modification;
INS	6	positive regulation of cell migration; endoplasmic reticulum lumen; Golgi lumen; protein binding; positive regulation of protein kinase B signaling cascade; extracellular region;
APOA1	6	endoplasmic reticulum lumen; plasma membrane; protein binding; blood coagulation; phospholipid binding; extracellular region;
EDEM2	5	cellular protein metabolic process; endoplasmic reticulum lumen; calcium ion binding; extracellular region; post-translational protein modification;
CANX	5	cellular protein metabolic process; endoplasmic reticulum lumen; protein binding; calcium ion binding; post-translational protein modification;
PRCP	5	blood coagulation, intrinsic pathway; plasma membrane; protein binding; blood coagulation; proteolysis;
PRSS8	5	plasma membrane; serine-type endopeptidase activity; protein binding; proteolysis; extracellular region;
SNCA	5	plasma membrane; protein binding; calcium ion binding; phospholipid binding; extracellular region;
ADAM8	5	plasma membrane; protein binding; proteolysis; calcium ion binding; positive regulation of protein kinase B signaling cascade;

Genes shared at least 2 KEGG pathways with F10 (count: 0)

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Region: chr13:113777128..113803843 View in gBrowse