ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PRSS8
Approved Name	protease, serine, 8
Name Alias	prostasin
Location	16p11.2
Position	chr16:31142754-31147151, -
External Links	HGNC: 9491 Entrez Gene: 5652 Ensembl: ENSG00000052344 UCSC: uc002ebc.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008236	serine-type peptidase activity	Molecular Function	TAS[8034638]	11
GO:0006508	proteolysis	Biological Process		102
GO:0016021	integral to membrane	Cellular Component		845
GO:0010765	positive regulation of sodium ion transport	Biological Process		5
GO:0004252	serine-type endopeptidase activity	Molecular Function		29
GO:0005576	extracellular region	Cellular Component	TAS[10077646]	240
GO:0005515	protein binding	Molecular Function	IPI[19911255]	910
GO:0005886	plasma membrane	Cellular Component	IDA[19911255]	772
GO:0005615	extracellular space	Cellular Component		126

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PRSS8 (count: 6)

Gene Symbol	Pathway Count	Pathway List
F7	6	serine-type peptidase activity; proteolysis; serine-type endopeptidase activity; extracellular region; plasma membrane; extracellular space;
ST14	5	serine-type peptidase activity; proteolysis; serine-type endopeptidase activity; extracellular region; plasma membrane;
CTSG	5	proteolysis; serine-type endopeptidase activity; extracellular region; plasma membrane; extracellular space;
F10	5	proteolysis; serine-type endopeptidase activity; extracellular region; protein binding; plasma membrane;
FURIN	5	proteolysis; integral to membrane; serine-type endopeptidase activity; plasma membrane; extracellular space;
GHR	5	integral to membrane; extracellular region; protein binding; plasma membrane; extracellular space;

Genes shared at least 2 KEGG pathways with PRSS8 (count: 0)

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Region: chr16:31142754..31147151 View in gBrowse