ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CMA1
Approved Name	chymase 1, mast cell
Location	14
Position	chr14:24974561-24977471, -
External Links	HGNC: 2097 Entrez Gene: 1215 Ensembl: ENSG00000092009 UCSC: uc001wpp.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004252	serine-type endopeptidase activity	Molecular Function	IDA[1919436]; NAS[8144971]	29
GO:0005622	intracellular	Cellular Component		67
GO:0005576	extracellular region	Cellular Component		240
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0030901	midbrain development	Biological Process		5
GO:0031012	extracellular matrix	Cellular Component		28
GO:0042277	peptide binding	Molecular Function		7
GO:0006508	proteolysis	Biological Process		102
GO:0006518	peptide metabolic process	Biological Process		3
GO:0008236	serine-type peptidase activity	Molecular Function	TAS[2071582]	11
GO:0022617	extracellular matrix disassembly	Biological Process		14
GO:0045766	positive regulation of angiogenesis	Biological Process		12
GO:0050720	interleukin-1 beta biosynthetic process	Biological Process	IDA[1919436]	1
GO:0050727	regulation of inflammatory response	Biological Process	IC[1919436]	8
GO:0071333	cellular response to glucose stimulus	Biological Process		8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04614	Renin-angiotensin system	4

Genes shared at least 5 GO terms with CMA1 (count: 5)

Gene Symbol	Pathway Count	Pathway List
CTSG	6	serine-type endopeptidase activity; extracellular region; extracellular matrix organization; extracellular matrix; proteolysis; extracellular matrix disassembly;
CTRB1	5	serine-type endopeptidase activity; extracellular region; extracellular matrix organization; proteolysis; extracellular matrix disassembly;
CTRB2	5	serine-type endopeptidase activity; extracellular region; extracellular matrix organization; proteolysis; extracellular matrix disassembly;
FURIN	5	serine-type endopeptidase activity; extracellular matrix organization; peptide binding; proteolysis; extracellular matrix disassembly;
MMP8	5	serine-type endopeptidase activity; extracellular region; extracellular matrix organization; proteolysis; extracellular matrix disassembly;

Genes shared at least 2 KEGG pathways with CMA1 (count: 0)

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Region: chr14:24974561..24977471 View in gBrowse