ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CTSL2
Symbol Alias	CTSU, CTSV
Approved Name	cathepsin L2
Location	9q22.33
Position	chr9:99794937-99801592, -
External Links	HGNC: 2538 Entrez Gene: 1515 Ensembl: ENSG00000136943 UCSC: uc004awt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0060008	Sertoli cell differentiation	Biological Process		2
GO:0051384	response to glucocorticoid stimulus	Biological Process		17
GO:0048102	autophagic cell death	Biological Process		2
GO:0046697	decidualization	Biological Process		1
GO:0043204	perikaryon	Cellular Component		12
GO:0043202	lysosomal lumen	Cellular Component		10
GO:0043005	neuron projection	Cellular Component		35
GO:0042277	peptide binding	Molecular Function		7
GO:0034698	response to gonadotropin stimulus	Biological Process		1
GO:0032403	protein complex binding	Molecular Function		27
GO:0030984	kininogen binding	Molecular Function		1
GO:0021675	nerve development	Biological Process		3
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process		14
GO:0010259	multicellular organismal aging	Biological Process		4
GO:0009897	external side of plasma membrane	Cellular Component		34
GO:0009749	response to glucose stimulus	Biological Process		10
GO:0004177	aminopeptidase activity	Molecular Function		6
GO:0004197	cysteine-type endopeptidase activity	Molecular Function		17
GO:0005902	microvillus	Cellular Component		8
GO:0006508	proteolysis	Biological Process		102
GO:0007283	spermatogenesis	Biological Process		35
GO:0008234	cysteine-type peptidase activity	Molecular Function	TAS[9563472]	10
GO:0009267	cellular response to starvation	Biological Process		3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04142	Lysosome	19	Lysosomes are membrane-delimited organelles in animal cells ...... Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. More...

Genes shared at least 5 GO terms with CTSL2 (count: 0)

Genes shared at least 2 KEGG pathways with CTSL2 (count: 0)

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Region: chr9:99794937..99801592 View in gBrowse