ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APOA4
Approved Name	apolipoprotein A-IV
Location	11q23.3
Position	chr11:116691419-116694022, -1
External Links	HGNC: 602 Entrez Gene: 337 Ensembl: ENSG00000110244 UCSC: uc001pps.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 46)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 46)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010898	positive regulation of triglyceride catabolic process	biological process	IDA[2307668]	4
GO:0046470	phosphatidylcholine metabolic process	biological process	IDA[1935934]	2
GO:0005507	copper ion binding	molecular function	IDA[16945374]	9
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS	35
GO:0043691	reverse cholesterol transport	biological process	IDA[3095477]	7
GO:0051006	positive regulation of lipoprotein lipase activity	biological process	IDA[2307668]	4
GO:0016209	antioxidant activity	molecular function	IDA[16945374]	3
GO:0065005	protein-lipid complex assembly	biological process	IMP[16159879]	1
GO:0006629	lipid metabolic process	biological process	TAS	51
GO:0045723	positive regulation of fatty acid biosynthetic process	biological process	IDA[2307668]	4
GO:0005576	extracellular region	cellular component	NAS[14718574]; TAS	267
GO:0042632	cholesterol homeostasis	biological process	IDA[1935934]	17
GO:0034378	chylomicron assembly	biological process	TAS[16159879]	1
GO:0042157	lipoprotein metabolic process	biological process	TAS	11
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	IDA[1935934]	2
GO:0042803	protein homodimerization activity	molecular function	IDA[1935934]	128
GO:0006982	response to lipid hydroperoxide	biological process	IDA[16945374]	1
GO:0044240	multicellular organismal lipid catabolic process	biological process	IDA[3095477]	2
GO:0031210	phosphatidylcholine binding	molecular function	IDA[1935934]	2
GO:0034371	chylomicron remodeling	biological process	IC[2307668]	3
GO:0005615	extracellular space	cellular component	IDA	133
GO:0030300	regulation of intestinal cholesterol absorption	biological process	IEA	2
GO:0009986	cell surface	cellular component	IDA[1935934]	75
GO:0008203	cholesterol metabolic process	biological process	IDA[1935934]	16
GO:0042744	hydrogen peroxide catabolic process	biological process	IDA[16945374]	6
GO:0043499	eukaryotic cell surface binding	molecular function	IDA[1935934]	2
GO:0034375	high-density lipoprotein particle remodeling	biological process	IC[1935934]	5
GO:0032374	regulation of cholesterol transport	biological process	IDA[11940599]	1
GO:0006869	lipid transport	biological process	IDA[1935934]	13
GO:0017127	cholesterol transporter activity	molecular function	IDA[1935934]	5
GO:0008289	lipid binding	molecular function	IMP[16159879]	23
GO:0010873	positive regulation of cholesterol esterification	biological process	IDA[1935934]	2
GO:0034372	very-low-density lipoprotein particle remodeling	biological process	IDA[2307668]	3
GO:0055088	lipid homeostasis	biological process	IDA[3095477]	4
GO:0019430	removal of superoxide radicals	biological process	IDA[16945374]	4
GO:0034364	high-density lipoprotein particle	cellular component	IDA[3095477]	3
GO:0002227	innate immune response in mucosa	biological process	IDA[15254593]	1
GO:0005319	lipid transporter activity	molecular function	TAS[3080432]	2
GO:0035634	response to stilbenoid	biological process	IEA	1
GO:0033344	cholesterol efflux	biological process	IDA[11162594]	8
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0034361	very-low-density lipoprotein particle	cellular component	IDA[17154273]	6
GO:0042627	chylomicron	cellular component	IDA[3095477]	5
GO:0007159	leukocyte cell-cell adhesion	biological process	IDA[15254593]	5
GO:0033700	phospholipid efflux	biological process	IDA[11162594]	5
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	biological process	IDA[16945374]	1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with APOA4 (count: 12)

Gene Symbol	Pathway Count	Pathway List
APOC2	18	positive regulation of triglyceride catabolic process; reverse cholesterol transport; positive regulation of lipoprotein lipase activity; lipid metabolic process; positive regulation of fatty acid biosynthetic process; extracellular region; cholesterol homeostasis; lipoprotein metabolic process; protein homodimerization activity; chylomicron remodeling; extracellular space; lipid binding; very-low-density lipoprotein particle remodeling; cholesterol efflux; small molecule metabolic process; very-low-density lipoprotein particle; chylomicron; phospholipid efflux;
APOA1	18	endoplasmic reticulum lumen; reverse cholesterol transport; lipid metabolic process; extracellular region; cholesterol homeostasis; lipoprotein metabolic process; phosphatidylcholine-sterol O-acyltransferase activator activity; extracellular space; regulation of intestinal cholesterol absorption; cholesterol metabolic process; high-density lipoprotein particle remodeling; cholesterol transporter activity; positive regulation of cholesterol esterification; high-density lipoprotein particle; cholesterol efflux; small molecule metabolic process; very-low-density lipoprotein particle; phospholipid efflux;
APOA5	14	positive regulation of triglyceride catabolic process; positive regulation of lipoprotein lipase activity; positive regulation of fatty acid biosynthetic process; extracellular region; cholesterol homeostasis; lipoprotein metabolic process; phosphatidylcholine binding; extracellular space; lipid transport; lipid binding; high-density lipoprotein particle; small molecule metabolic process; very-low-density lipoprotein particle; chylomicron;
APOC3	13	reverse cholesterol transport; lipid metabolic process; extracellular region; cholesterol homeostasis; lipoprotein metabolic process; extracellular space; cholesterol metabolic process; high-density lipoprotein particle remodeling; cholesterol efflux; small molecule metabolic process; very-low-density lipoprotein particle; chylomicron; phospholipid efflux;
LPL	10	lipid metabolic process; extracellular region; lipoprotein metabolic process; chylomicron remodeling; extracellular space; cell surface; very-low-density lipoprotein particle remodeling; small molecule metabolic process; very-low-density lipoprotein particle; chylomicron;
ABCA1	9	reverse cholesterol transport; lipid metabolic process; cholesterol homeostasis; lipoprotein metabolic process; cholesterol metabolic process; cholesterol transporter activity; cholesterol efflux; small molecule metabolic process; phospholipid efflux;
SCARB1	9	reverse cholesterol transport; lipid metabolic process; cholesterol homeostasis; lipoprotein metabolic process; protein homodimerization activity; cell surface; high-density lipoprotein particle remodeling; cholesterol efflux; small molecule metabolic process;
ACHE	6	endoplasmic reticulum lumen; extracellular region; protein homodimerization activity; extracellular space; cell surface; small molecule metabolic process;
PLA2G1B	5	phosphatidylcholine metabolic process; extracellular region; multicellular organismal lipid catabolic process; extracellular space; small molecule metabolic process;
LIPG	5	reverse cholesterol transport; lipid metabolic process; cholesterol homeostasis; extracellular space; high-density lipoprotein particle remodeling;
CUBN	5	lipid metabolic process; lipoprotein metabolic process; protein homodimerization activity; cholesterol metabolic process; small molecule metabolic process;
APOL4	5	lipid metabolic process; lipoprotein metabolic process; extracellular space; lipid transport; lipid binding;

Genes shared at least 2 KEGG pathways with APOA4 (count: 0)

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Region: chr11:116691419..116694022 View in gBrowse