ADHDgene Database

Gene Report

Basic Info

Approved Symbol	UNC5B
Symbol Alias	UNC5H2, p53RDL1
Approved Name	unc-5 homolog B (C. elegans)
Previous Name	unc5 (C.elegans homolog) b
Location	10q22.2
Position	chr10:72972298-73062621, +
External Links	HGNC: 12568 Entrez Gene: 219699 Ensembl: ENSG00000107731 UCSC: uc001jro.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs16928529	Chr10:72982985(Fwd)	intron_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016021	integral to membrane	Cellular Component		845
GO:0007411	axon guidance	Biological Process		65
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Biological Process	IMP[18469807]	2
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0005515	protein binding	Molecular Function	IPI[18469807]	910
GO:0007165	signal transduction	Biological Process		171
GO:0006915	apoptotic process	Biological Process		111

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with UNC5B (count: 0)

Genes shared at least 2 KEGG pathways with UNC5B (count: 0)

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Region: chr10:72972298..73062621 View in gBrowse