ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SRGAP1
Symbol Alias	KIAA1304, ARHGAP13
Approved Name	SLIT-ROBO Rho GTPase activating protein 1
Location	12q13.13
Position	chr12:64238541-64541613, +
External Links	HGNC: 17382 Entrez Gene: 57522 Ensembl: ENSG00000196935 UCSC: uc010ssp.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.0000106 locates intronic relative to this gene.	Trend

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11175219	Chr12:64362719(Fwd)	intron_variant; nc_transcript_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs789738	Chr12:64536009(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs12227635	Chr12:64358475(Fwd)	intron_variant; nc_transcript_variant
rs699629	Chr12:64521141(Fwd)	intron_variant; upstream_gene_variant
rs17711166	Chr12:64447812(Fwd)	intron_variant; nc_transcript_variant
rs17099949	Chr12:64336805(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	No. of Genes in ADHDgene
GO:0007264	small GTPase mediated signal transduction	Biological Process	58
GO:0005829	cytosol	Cellular Component	447
GO:0007411	axon guidance	Biological Process	65
GO:0007266	Rho protein signal transduction	Biological Process	11
GO:0005100	Rho GTPase activator activity	Molecular Function	6
GO:0017048	Rho GTPase binding	Molecular Function	3
GO:0016477	cell migration	Biological Process	24
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process	30

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with SRGAP1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
ARHGAP5	5	small GTPase mediated signal transduction; cytosol; Rho protein signal transduction; Rho GTPase activator activity; regulation of small GTPase mediated signal transduction;

Genes shared at least 2 KEGG pathways with SRGAP1 (count: 0)

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Region: chr12:64238541..64541613 View in gBrowse