ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PPP1R1B
Symbol Alias	DARPP-32, FLJ20940
Approved Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Name Alias	dopamine and cAMP regulated phosphoprotein
Location	17
Position	chr17:37783179-37792879, +
External Links	HGNC: 9287 Entrez Gene: 84152 Ensembl: ENSG00000131771 UCSC: uc002hrz.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Laurin N, 2008(c)	no evidence of association of individual marker alleles and haplotypes	Non-significant

Gene related SNPs (count: 6)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs907094	Chr17:37790371(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1495099	Chr17:37784464(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant	1(0/1/0)
rs879606	Chr17:37781849(Fwd)	downstream_gene_variant; upstream_gene_variant	1(0/1/0)
rs3764352	Chr17:37790939(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs2271309	Chr17:37784990(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs10852934	Chr17:37782410(Fwd)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component		447
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006469	negative regulation of protein kinase activity	Biological Process	TAS[10604473]	13
GO:0007165	signal transduction	Biological Process	TAS[10604473]	171
GO:0007621	negative regulation of female receptivity	Biological Process		1
GO:0008542	visual learning	Biological Process		12
GO:0008599	protein phosphatase type 1 regulator activity	Molecular Function		2
GO:0035556	intracellular signal transduction	Biological Process		44
GO:0043025	neuronal cell body	Cellular Component		51
GO:0001975	response to amphetamine	Biological Process		16
GO:0005634	nucleus	Cellular Component		770
GO:0005102	receptor binding	Molecular Function		61
GO:0004864	protein phosphatase inhibitor activity	Molecular Function	TAS[10604473]	6
GO:0004860	protein kinase inhibitor activity	Molecular Function	TAS[10604473]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PPP1R1B (count: 7)

Gene Symbol	Pathway Count	Pathway List
PRKCB	6	cytoplasm; cytosol; transcription, DNA-dependent; signal transduction; intracellular signal transduction; nucleus;
APBB1	5	cytoplasm; transcription, DNA-dependent; signal transduction; visual learning; nucleus;
CTNND1	5	cytoplasm; cytosol; transcription, DNA-dependent; nucleus; receptor binding;
GSK3B	5	cytoplasm; cytosol; intracellular signal transduction; neuronal cell body; nucleus;
MAPK1	5	cytoplasm; cytosol; transcription, DNA-dependent; signal transduction; nucleus;
NR4A2	5	cytoplasm; transcription, DNA-dependent; signal transduction; response to amphetamine; nucleus;
RASA1	5	cytoplasm; cytosol; signal transduction; intracellular signal transduction; receptor binding;

Genes shared at least 2 KEGG pathways with PPP1R1B (count: 0)

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Region: chr17:37783179..37792879 View in gBrowse