ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

GO Report

Basic Info

ID	GO:0005245
Name	voltage-gated calcium channel activity
Type	Molecular Function
No. of Genes in ADHDgene	22
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 22)

Literature-origin genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GRM7	glutamate receptor, metabotropic 7	3p26-p25	1(1/0/0)
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	12p13.3	1(0/1/0)	IDA[8392192]
OPRM1	opioid receptor, mu 1	6q24-q25	1(1/0/0)

Genes from other sources (count: 19)

Approved Symbol	Approved Name	Source	Evidence[PMID]
CACNA1F	calcium channel, voltage-dependent, L type, alpha 1F subunit	Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP	IDA[15897456]
TPCN2	two pore segment channel 2	Mapped by CNV; Mapped by significant region
CATSPER1	cation channel, sperm associated 1	Mapped by significant region
CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	Mapped by PBA pathway	IDA[9852570]
CACNB2	calcium channel, voltage-dependent, beta 2 subunit	Mapped by PBA pathway	IDA[1309651]
CACNG5	calcium channel, voltage-dependent, gamma subunit 5	Mapped by PBA pathway	TAS[10613843]
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mapped by PBA pathway
CACNG1	calcium channel, voltage-dependent, gamma subunit 1	Mapped by PBA pathway
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	Mapped by PBA pathway
CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	Mapped by CNV	TAS[10454147]
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	Mapped by PBA pathway	IDA[16525042]
CACNB1	calcium channel, voltage-dependent, beta 1 subunit	Mapped by PBA pathway	TAS[1385409]
CACNB3	calcium channel, voltage-dependent, beta 3 subunit	Mapped by PBA pathway	IDA[11160515]
RYR1	ryanodine receptor 1 (skeletal)	Mapped by PBA pathway
CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mapped by PBA pathway
CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	Mapped by PBA pathway	IDA[1309651,11160515]
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mapped by PBA pathway	IDA[12451115]
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mapped by PBA pathway; Mapped by significant region	IDA[8071363]
CACNG4	calcium channel, voltage-dependent, gamma subunit 4	Mapped by PBA pathway