ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

SNP Report

Basic Info

Name	rs583668 dbSNP Ensembl
Location	chr16:33967254(Fwd); chr2:133009053(Rev); chrY:10039596(Fwd)
Variant Alleles	A/G
Functional Annotation	downstream_gene_variant; upstream_gene_variant; intron_variant; nc_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000363564) upstream_gene_variant(ENST00000539813; ENST00000365304) intron_variant(ENST00000470729) nc_transcript_variant(ENST00000470729; ENST00000515896; ENST00000445125)
No. of Studies	3 (significant: 2; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Deupree JD, 2006	C/T		FBAT P-value=0.024 for the affected, FBAT P-value=0.02 for t...... FBAT P-value=0.024 for the affected, FBAT P-value=0.02 for the hyperactive, FBAT P-value=0.015 for the inattentive, FBAT P-value=0.019 for the total sample, with the additive model; P-value=0.038 for the inattentive, P-value=0.039 for the hyperactive, with the dominant model; TDT P-value=0.068, sigma² (1df) =3.33 for allele 1 More...	detected significant linkage disequilibrium with the DraI po...... detected significant linkage disequilibrium with the DraI polymorphism and all of the ADHD phenotypes using the FBAT analysis and the additive model, and only significant for the ADHD inattentive and hyperactive phenotype with the dominant model More...	Significant
Wang B, 2006	C/T		TDT P-value=0.656, McNemar X²=0.198 for ADHD phen...... TDT P-value=0.656, McNemar X²=0.198 for ADHD phenotype; TDT P-value=0.21, McNemar X²=1.568 for ADHD-C phenotype; TDT P-value=0.541 for ADHD-HI phenotype; TDT P-value=0.94, McNemar X²=0.006 for ADHD-I phenotype More...	no biased transmission of any allele was observed no biased transmission of any allele was observed	Non-significant
Cho SC, 2008(b)			genotype or allele frequencies P-value>0.05; TDT P-value=0.0...... genotype or allele frequencies P-value>0.05; TDT P-value=0.015, X²=5.88 for allele C More...	showed preferential transmission of the C allele showed preferential transmission of the C allele	Significant

SNP related genes (count: 6)

Literature-origin genes (count: 0)

Genes from other sources (count: 6)

Approved Symbol	Approved Name	Location
LINC00273	long intergenic non-protein coding RNA 273	16p11.2
RNA5-8SP5	RNA, 5.8S ribosomal pseudogene 5	2q21.2
RNA5-8SP6	RNA, 5.8S ribosomal pseudogene 6	Yp11.2
RNA45S5	RNA, 45S pre-ribosomal 5	22p12
RNA5-8SP2	RNA, 5.8S ribosomal pseudogene 2	16p11.2
ANKRD30BL	ankyrin repeat domain 30B-like	2q21.2

SNPs in LD with rs583668 (count: 0) View in gBrowse (chrY:10039596..10039596 )