ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Other Variant Report

Basic Info

Name	DRD2_TaqI
Type	point mutation
Related Gene	DRD2
No. of Study	5 (significant: 1; non-significant 4; trend: 0)

Variant related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Huang YS, 2003	A1/A2		allelic HHRR P-value=0.557, X²=0.3 in total; alle...... allelic HHRR P-value=0.557, X²=0.3 in total; allelic HHRR P-value=0.842, X²=0.04 in sporadic cases; allelic HHRR P-value=0.273, X²=1.2 in familial cases; allelic HHRR P-value=0.544, X²=0.4 in male; allelic HHRR P-value=0.952, X²=0.004 in female More...	there was no significant difference in transmission rates be...... there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles More...	Non-significant
Comings DE, 1991	A1/A2	A1	chi-square P-value=0.0003, X²-1=14.64 for ADHD co...... chi-square P-value=0.0003, X²-1=14.64 for ADHD compared with the total controls; chi-square P-value=0.0001, X²-2=17.30 for ADHD compared with the controls known to be nonalcoholic; chi-square P-value=0.02, X²-1=5.26 for ADHD secondary to TS compared with the total controls; chi-square P-value=0.002, X²-2=10.00 for ADHD compared with the controls known to be nonalcoholic; chi-square P-value=0.0001, X²-1=17.44 for ADHD and ADHD secondary to TS compared with the total controls; chi-square P-value=0.0001, X²-2=18.66 for ADHD and ADHD secondary to TS compared with the controls known to be nonalcoholic More...	The prevalence of the A1 allele was significantly increased ...... The prevalence of the A1 allele was significantly increased in patients with ADHD. More...	Significant
Rowe DC, 1999	A1/A2	A1	X² test: P=0.035 (df=1) for additive genetic effe...... X² test: P=0.035 (df=1) for additive genetic effects on HI symptoms in the situation without parental mating types as controls; P=0.003 (df=2) for additive plus dominance genetic effects on HI symptoms in the situation without parental mating types as controls. More...	None of the results with the test that included parental mat...... None of the results with the test that included parental mating types as controls were significant. More...	Non-significant
Kirley A, 2002			HHRR: P-value=0.18 (RR=1.2, OR=1.5); TDT: P-value=0.511 (OR=...... HHRR: P-value=0.18 (RR=1.2, OR=1.5); TDT: P-value=0.511 (OR=1.31); TDT by presence of family history: P-value=0.238 (OR[95%CI]=0.32[0.06-1.64]); TDT of Paternal and Maternal transmissions: P-value=0.67 (OR[95%CI]=0.71[0.15-3.33]) More...	trends for association trends for association	Non-significant
Kustanovich V, 2004			GRR=1.43, TDT P-value=0.583 GRR=1.43, TDT P-value=0.583	No evidence for an association was found No evidence for an association was found	Non-significant