Study Report

Basic Info
Reference |
Huang YS, 200315008324
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Citation |
Huang Y. S., Lin S. K., Wu Y. Y., Chao C. C. and Chen C. K. (2003) "A family-based association study of attention-deficit hyperactivity disorder and dopamine D2 receptor TaqI A alleles." Chang Gung Med J, 26(12): 897-903.
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Study Design |
family-based |
Study Type |
Candidate-gene association study |
Sample Size |
98 children with ADHD and 154 of their parents |
Predominant Ethnicity |
Mongoloid |
Population |
China |
Gender |
83 males and 15 females |
Age Group |
Children/Adolescents
:
5-15 years, with a mean of 8.8 (SD=2.5) years
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Detail Info
Summary |
In this study, they investigated the association of the dopamine D2 receptor (DAD2) TaqI A and ADHD in a Taiwanese sample. The sample consisted of 98 children with ADHD and 154 of their parents. ADHD cases were ascertained from the Child Psychiatric Clinics at Chang Gung Memorial Hospital in the Taipei area, Taiwan. A diagnosis of ADHD was made following clinical interviews plus completion of a standard maternal interview and Conner's revised rating scales by a parent and teacher. Association of DRD2 TaqI A polymorphism in this sample was investigated using a haplotype-based haplotype relative-risk method. Among their subjects, there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles. |
Total Sample |
The sample consisted of 98 children with ADHD and 154 of their parents. The age of the subjects ranged from 5 to 15 years, with a mean of 8.8 (SD=2.5) years. Among the subject, 83 (84.7%) were male and 16 (15.3%) were female. Among these 98 probands, 16 had siblings with ADHD, and were grouped as familial cases. |
Sample Collection |
In total, 98 subjects (83 males and 15 females) were recruited from children being assessed and/or treated for ADHD at the Department of Child Psychiatry, Chang Gung Children's Hospital, Taipei. |
Diagnosis Description |
All subjects were assessed with (1) the Conners Child Activity Rating Scale completed by a caretaker and teacher; (2) a clinical diagnosis by a board-certificated child psychiatrist; (3) and a clinical interview or structured interview with the Schedule for Affective Disorder and Schizophrenia for School-Age Children, Adolescent Version (K-SADS-E) by an experienced child psychiatrist. |
Technique |
Buccal cells were collected from subjects and their parents by the cheek swab method. DNA extraction was performed using commercial kits. Restriction fragment length polymorphism analysis of TaqI A polymorphism of the DRD2 gene was carried out using a polymerase chain reaction (PCR)- based restriction analysis according to the method described by Grandy et al. |
Analysis Method |
Analysis of allele associations was performed using a haplotype-based haplotype relative-risk method (HHRR). |
Result Description |
Among their subjects, there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles. The results of this study do not support DRD2 playing a major role in Taiwanese children with ADHD. |

Other variant reported by this study (count: 1)
Variant Name |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
DRD2 TaqI |
A1/A2 |
|
allelic HHRR P-value=0.557, X2=0.3 in total; alle......
allelic HHRR P-value=0.557, X2=0.3 in total; allelic HHRR P-value=0.842, X2=0.04 in sporadic cases; allelic HHRR P-value=0.273, X2=1.2 in familial cases; allelic HHRR P-value=0.544, X2=0.4 in male; allelic HHRR P-value=0.952, X2=0.004 in female
More...
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there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles |
Non-significant
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Genes reported by this study (count: 1)
Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
DRD2 |
there was no significant difference in transmission rates be......
there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles
More...
|
Non-significant
|