ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Huang YS, 200315008324
Citation	Huang Y. S., Lin S. K., Wu Y. Y., Chao C. C. and Chen C. K. (2003) "A family-based association study of attention-deficit hyperactivity disorder and dopamine D2 receptor TaqI A alleles." Chang Gung Med J, 26(12): 897-903.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	98 children with ADHD and 154 of their parents
Predominant Ethnicity	Mongoloid
Population	China
Gender	83 males and 15 females
Age Group	Children/Adolescents : 5-15 years, with a mean of 8.8 (SD=2.5) years

Detail Info

Summary	In this study, they investigated the association of the dopamine D2 receptor (DAD2) TaqI A and ADHD in a Taiwanese sample. The sample consisted of 98 children with ADHD and 154 of their parents. ADHD cases were ascertained from the Child Psychiatric Clinics at Chang Gung Memorial Hospital in the Taipei area, Taiwan. A diagnosis of ADHD was made following clinical interviews plus completion of a standard maternal interview and Conner's revised rating scales by a parent and teacher. Association of DRD2 TaqI A polymorphism in this sample was investigated using a haplotype-based haplotype relative-risk method. Among their subjects, there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles.
Total Sample	The sample consisted of 98 children with ADHD and 154 of their parents. The age of the subjects ranged from 5 to 15 years, with a mean of 8.8 (SD=2.5) years. Among the subject, 83 (84.7%) were male and 16 (15.3%) were female. Among these 98 probands, 16 had siblings with ADHD, and were grouped as familial cases.
Sample Collection	In total, 98 subjects (83 males and 15 females) were recruited from children being assessed and/or treated for ADHD at the Department of Child Psychiatry, Chang Gung Children's Hospital, Taipei.
Diagnosis Description	All subjects were assessed with (1) the Conners Child Activity Rating Scale completed by a caretaker and teacher; (2) a clinical diagnosis by a board-certificated child psychiatrist; (3) and a clinical interview or structured interview with the Schedule for Affective Disorder and Schizophrenia for School-Age Children, Adolescent Version (K-SADS-E) by an experienced child psychiatrist.
Technique	Buccal cells were collected from subjects and their parents by the cheek swab method. DNA extraction was performed using commercial kits. Restriction fragment length polymorphism analysis of TaqI A polymorphism of the DRD2 gene was carried out using a polymerase chain reaction (PCR)- based restriction analysis according to the method described by Grandy et al.
Analysis Method	Analysis of allele associations was performed using a haplotype-based haplotype relative-risk method (HHRR).
Result Description	Among their subjects, there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles. The results of this study do not support DRD2 playing a major role in Taiwanese children with ADHD.

Other variant reported by this study (count: 1)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
DRD2 TaqI	A1/A2		allelic HHRR P-value=0.557, X²=0.3 in total; alle...... allelic HHRR P-value=0.557, X²=0.3 in total; allelic HHRR P-value=0.842, X²=0.04 in sporadic cases; allelic HHRR P-value=0.273, X²=1.2 in familial cases; allelic HHRR P-value=0.544, X²=0.4 in male; allelic HHRR P-value=0.952, X²=0.004 in female More...	there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles	Non-significant

Genes reported by this study (count: 1)