ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name SLC6A3_intron8_VNTR
Type VNTR
Location intron 8
Length of Repeat Unit 30bp
Related Gene SLC6A3
No. of Study 11 (significant: 5; non-significant 6; trend: 0)

Variant related studies (count: 11)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Gizer IR, 2009 Meta-analysis model: Random: OR=1.25, 95% CI=0.98-1.58, P-va...... Meta-analysis model: Random: OR=1.25, 95% CI=0.98-1.58, P-value=0.034; Q-statistic: P-value=0.012, I2=64 More... significant but modest association significant but modest association Significant
Asherson P, 2007 TDT P-value=0.0132 for intron8 VNTR; 5R: TDT P-value=0.007, ...... TDT P-value=0.0132 for intron8 VNTR; 5R: TDT P-value=0.007, OR=0.81; 6R: TDT P-value=0.03, OR=1.19; 9R: TDT P-value=0.03, OR=2.2 More... global evidence for association with the intron 8 VNTR; 5R, ...... global evidence for association with the intron 8 VNTR; 5R, 6R and 9R were associated with risk for ADHD More... Significant
Brookes KJ, 2006(b) TDT P-value=0.006 in English group; TDT P-value=0.03 in Taiw...... TDT P-value=0.006 in English group; TDT P-value=0.03 in Taiwanese group More... associated in both populations with global significance associated in both populations with global significance Significant
Spencer, T. J., 2012 6R P-value=NS, X2=0.13 P-value=NS, X2=0.13 the gene frequencies of each of the gene polymorphisms asses...... the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups. More... Non-significant
Franke B, 2008 Pearson chi-square P-value=0.731, OR=1 for 6/6 genotype freq...... Pearson chi-square P-value=0.731, OR=1 for 6/6 genotype frequency, OR=0.93 for 6/5 genotype frequency, OR=0.73 for 5/5 genotype frequency More... genotype analysis did not show significant differences betwe...... genotype analysis did not show significant differences between cases and controls More... Non-significant
Bruggemann D, 2007 no P-value no P-value no association was found when testing single markers no association was found when testing single markers Non-significant
Genro JP, 2008 5/6 repeats 5 repeat P-value=0.489 for total sample, P-value=0.592 for c...... 5 repeat P-value=0.489 for total sample, P-value=0.592 for combined sample; 6 repeat P-value=0.614 for total sample; P-value=0.917 for combined sample More... no allele was significantly more transmitted than expected no allele was significantly more transmitted than expected Non-significant
Silva MA, 2009 4-7, 10 repeat 6-repeat allelic chi-square test P-value=0.038 allelic chi-square test P-value=0.038 The 6-repeat allele was statistically associated with ADHD The 6-repeat allele was statistically associated with ADHD Significant
Das M, 2011 ETDT P-value=0.1, X2(1df)=2.77, RR=7.71e+007; all...... ETDT P-value=0.1, X2(1df)=2.77, RR=7.71e+007; allelic frequencies COCAPHASE P-value=0.8, X2=0.07 for 11R; ETDT P-value=0.53, X2(1df)=0.4, RR=0.53; allelic frequencies COCAPHASE P-value=0.056, X2=3.64 for 10R; ETDT P-value=0.31, X2(1df)=1.02, RR=1.8; allelic frequencies COCAPHASE P-value=0.28, X2=1.17 for 9R; ETDT P-value=0.34, X2(1df)=0.89, RR=0.81; allelic frequencies COCAPHASE P-value=0.002, X2=9.59 for 6R; ETDT P-value=0.53, X2(1df)=0.4, RR=1; allelic frequencies COCAPHASE P-value=0.02, X2=5.49 for 5R; allelic frequencies COCAPHASE P-value=0.29, X2=1.13 for 7R More... the data was statistically not significant in either case-co...... the data was statistically not significant in either case-control or family-based analysis for 11R, 10R, 9R and 7R; the 6R allele showed significantly lower frequency in ADHD case group but ETDT analysis failed to show any bias in transmission; the 5R allele showed significantly higher occurrence in ADHD case group but ETDT analysis failed to show any bias in transmission More... Significant
Ilott NE, 2010 QTDT AT P-value=0.18, X2=3.42, df=2, QTDT AW P-va...... QTDT AT P-value=0.18, X2=3.42, df=2, QTDT AW P-value=0.24, X2=2.84, df=2 at age 2; QTDT AT P-value=0.24, X2=2.9, df=2, QTDT AW P-value=0.2, X2=3.21, df=2 at age 3 More... no significant association no significant association Non-significant
Franke B, 2010 no P-value no P-value no significant association no significant association Non-significant