Yang B, 2007 17440978
||Yang B., Chan R. C., Jing J., Li T., Sham P. and Chen R. Y. (2007) "A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder." Am J Med Genet B Neuropsychiatr Genet, 144B(4): 541-50.
||Candidate association study
||This study aimed to conduct a meta-analysis of the association between the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region (UTR) of the DAT1 gene and ADHD. They pooled up 18 published transmission disequilibrium test (TDT) studies between the 40-base pair VNTR polymorphism in the 3'-UTR of the DAT1 gene and ADHD. It included a total of 1,373 informative meioses, 7 haplotype-based haplotype relative risk (HHRR) studies, and 6 case-control-based association studies. There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies (P-value<0.10), but not in case-control studies. The results of random effects model showed small but significant association between ADHD and the DAT1 gene in TDT studies, but not in HHRR and case-control studies. The 10-repeat allele of a VNTR polymorphismin the 3'-UTR the DAT1 gene has a small but significant role in the genetic susceptibility of ADHD. These meta-analysis findings support the involvement of the dopamine system genes in ADHD liability variation. However, more work is required to further identify the functional allelic variants/mutations that are responsible for this association.
Genes reported by this study: 1