ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name HTR2A_His452Tyr
Type point mutation
Related Gene HTR2A
No. of Study 3 (significant: 3; non-significant 0; trend: 0)

Variant related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Quist JF, 2000 His/Tyr TDT P-value=0.03 TDT P-value=0.03 preferential transmission of the 452Tyr allele was found preferential transmission of the 452Tyr allele was found Significant
Hawi Z, 2002 His/Tyr HHRR P-value=0.82 (RR [95% CI]= 0.98 [0.79-1.21], TDT P-valu...... HHRR P-value=0.82 (RR [95% CI]= 0.98 [0.79-1.21], TDT P-value=1 (OR=0.98) in Total sample; HHRR P-value=0.026 (RR [95% CI]= 1.9 [0.95-3.80], TDT P-value=0.052 (OR=2.76) in Ireland sample; HHRR P-value=0.29 (RR [95% CI]=1.19 [0.88-1.61], TDT P-value=0.26 (OR=0.61) in Wales/Manchester sample; HHRR P-value=0.26 (RR [95% CI]= 1.84 [0.70-2.96], TDT P-value=0.42 (OR=1.8) in England/Birmingham sample; HHRR P-value=0.17 (RR [95% CI]= 0.76 [0.54-1.08], TDT P-value=0.13 (OR=2.14) in England/London sample More... Analysis of HTR2A failed to reveal evidence of association o...... Analysis of HTR2A failed to reveal evidence of association or linkage between the His452Tyr polymorphism and ADHD in the total sample. However, a significantly increased transmission of the allele 452His was observed in the Irish sample alone. More... Significant
Guimaraes AP, 2007 His/Tyr HRR P-value=0.07 (OR=1.53[0.93-2.53]) in total samples; HRR ...... HRR P-value=0.07 (OR=1.53[0.93-2.53]) in total samples; HRR P-value=0.04 (OR=1.7[0.99-2.97]) in boys samples. More... a trend association between this polymorphism and ADHD was d...... a trend association between this polymorphism and ADHD was detected More... Significant