ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Other Variant Report

Basic Info

Name	HTR2A_His452Tyr
Type	point mutation
Related Gene	HTR2A
No. of Study	3 (significant: 3; non-significant 0; trend: 0)

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Guimaraes AP, 2007	His/Tyr		HRR P-value=0.07 (OR=1.53[0.93-2.53]) in total samples; HRR ...... HRR P-value=0.07 (OR=1.53[0.93-2.53]) in total samples; HRR P-value=0.04 (OR=1.7[0.99-2.97]) in boys samples. More...	a trend association between this polymorphism and ADHD was d...... a trend association between this polymorphism and ADHD was detected More...	Significant
Hawi Z, 2002	His/Tyr		HHRR P-value=0.82 (RR [95% CI]= 0.98 [0.79-1.21], TDT P-valu...... HHRR P-value=0.82 (RR [95% CI]= 0.98 [0.79-1.21], TDT P-value=1 (OR=0.98) in Total sample; HHRR P-value=0.026 (RR [95% CI]= 1.9 [0.95-3.80], TDT P-value=0.052 (OR=2.76) in Ireland sample; HHRR P-value=0.29 (RR [95% CI]=1.19 [0.88-1.61], TDT P-value=0.26 (OR=0.61) in Wales/Manchester sample; HHRR P-value=0.26 (RR [95% CI]= 1.84 [0.70-2.96], TDT P-value=0.42 (OR=1.8) in England/Birmingham sample; HHRR P-value=0.17 (RR [95% CI]= 0.76 [0.54-1.08], TDT P-value=0.13 (OR=2.14) in England/London sample More...	Analysis of HTR2A failed to reveal evidence of association o...... Analysis of HTR2A failed to reveal evidence of association or linkage between the His452Tyr polymorphism and ADHD in the total sample. However, a significantly increased transmission of the allele 452His was observed in the Irish sample alone. More...	Significant
Quist JF, 2000	His/Tyr		TDT P-value=0.03 TDT P-value=0.03	preferential transmission of the 452Tyr allele was found preferential transmission of the 452Tyr allele was found	Significant