ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Other Variant Report

Basic Info

Name	HTR2A_T102C
Type	point mutation
Related Gene	HTR2A
No. of Study	4 (significant: 1; non-significant 3; trend: 0)

Variant related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Cho, S. C., 2012	T/C		genotypic P-value=0.078, allelic P-value=0.153, grouping P-v...... genotypic P-value=0.078, allelic P-value=0.153, grouping P-value=0.899 with or without T allele, grouping P-value=0.030 with or without C allele between ADHD probands and controls; genotypic P-value=0.049, allelic P-value=0.181, grouping P-value=0.882 with or without T allele, grouping P-value=0.023 with or without C allele between the probands of ADHD combined type and controls; TDT P-value=1.000, X²=0.00, df=1 More...	The frequency distribution of the 3 genotypes among the enti...... The frequency distribution of the 3 genotypes among the entire ADHD patient group and the control group did not reveal any statistical differences, though the T/C type tended to appear more frequently in the patient group. Moreover, the frequency distributions of the groups according to the presence of T allele were also examined, and no statistical difference was detected between the case and the control group. However, comparison of the distributions between the case and control groups according to the presence of C allele showed that there were significant differences between the groups with and withoutC allele. In addition, an association analysis was conducted between the control group and the combined-type ADHD subtype. The results indicated that there were significant differences in the frequency distributions of the 3 genotypes between the case group and the control group. Furthermore, comparison of the distributions between the case and control groups according to alleles also showed that there were significant differences between the groups with and without C allele. However, there were no significant differences in allele frequency or classification according to the presence of the T allele. A TDT analysis was conducted on the entire family group of the patient-parent trios, but the selective transmission of a specific allele was not observed. Likewise, no selective transmission of a specific allele was observed in the trios of the combined-type ADHD patient families. More...	Significant
Li J, 2006(e)	C/T		TDT P-value=0.428, McNemar X²=0.628 TDT P-value=0.428, McNemar X²=0.628	no biased transmission of any alleles was observed no biased transmission of any alleles was observed	Non-significant
Quist JF, 2000	T/C		TDT P-value=0.41 TDT P-value=0.41	no evidence for biased transmission of alleles of the HTR2A ...... no evidence for biased transmission of alleles of the HTR2A T102C More...	Non-significant
Zoroglu SS, 2003	T/C		allelic chi-square test P-value=0.89, X²(1df)=0.0...... allelic chi-square test P-value=0.89, X²(1df)=0.02; genotypic chi-square test P-value=0.53, X²(2df)=1.25 More...	no significant differences between patients and controls wer...... no significant differences between patients and controls were found neither in the distribution of the genotypes nor in the allele frequency More...	Non-significant