ADHDgene Database

SNP Report

Basic Info

Name	rs2229126 dbSNP Ensembl
Location	chr8:26627672(Fwd)
Variant Alleles	T/A
Ancestral Allele	T
Functional Annotation	downstream_gene_variant; intron_variant; missense_variant; NMD_transcript_variant; upstream_gene_variant. Polyphen Annotation: benign(ENST00000276393; ENST00000380573) SIFT Annotation: tolerated(ENST00000276393; ENST00000380573)
Consequence to Transcript	downstream_gene_variant(ENST00000518621) intron_variant(ENST00000354550; ENST00000380581; ENST00000380582; ENST00000380586; ENST00000380587; ENST00000519096; ENST00000519229; ENST00000521711) missense_variant(ENST00000276393; ENST00000380573) NMD_transcript_variant(ENST00000519096; ENST00000521711) upstream_gene_variant(ENST00000486251)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/T		UNPHASED TDT P-value=0.15; WHAP TDT P-value=0.042 UNPHASED TDT P-value=0.15; WHAP TDT P-value=0.042	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
ADRA1A	adrenoceptor alpha 1A	8p21.2	3(2/1/0)

SNPs in LD with rs2229126 (count: 3) View in gBrowse (chr8:26616143..26662246 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs7835853	intron_variant; nc_transcript_variant; NMD_transcript_variant	1.0[CHB]; 1.0[JPT]
rs17055948	intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs10102186	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]