ADHDgene Database

SNP Report

Basic Info

Name	rs577366 dbSNP Ensembl
Location	Chr8:26697365(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000519096; ENST00000521711) intron_variant(ENST00000380582; ENST00000354550; ENST00000380586; ENST00000276393; ENST00000519229; ENST00000519096; ENST00000521711; ENST00000380573; ENST00000380572; ENST00000380587; ENST00000518621; ENST00000380581) nc_transcript_variant(ENST00000518621) upstream_gene_variant(ENST00000519826)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Hawi, Z., 2012	T:C	T	P-value=0.5079, X²=0.44, OR=1.12, 95% CI=0.81- 1....... P-value=0.5079, X²=0.44, OR=1.12, 95% CI=0.81- 1.54 More...	The marker did not show significant association with ADHD. The marker did not show significant association with ADHD.	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
ADRA1A	adrenergic, alpha-1A-, receptor	8p21.2	3(2/1/0)

Approved Symbol	Approved Name	Location
COX6B1P4	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) pseudogene 4	8p21.2

SNPs in LD with rs577366 (count: 12) View in gBrowse (chr8:26685346..26711990 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs472151	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/1/0)	0.91[JPT]

rs_ID	Functional Annotation	r²[population]
rs498989	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.826[JPT]
rs557754	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.944[YRI]
rs544104	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[JPT]; 0.846[YRI]
rs13282250	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs538898	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CHB]; 0.911[JPT]
rs511662	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.911[JPT]; 1.0[YRI]
rs527340	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.828[CEU]; 0.928[CHB]; 0.911[JPT]; 1.0[YRI]
rs13256192	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.811[CEU]
rs526302	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.947[CEU]; 1.0[CHB]; 0.91[JPT]; 0.846[YRI]
rs488323	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.91[JPT]
rs486354	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CHB]; 0.904[JPT]; 0.855[YRI]