ADHDgene Database

Gene Report

Basic Info

Approved Symbol	IKBKAP
Previous Symbol	DYS
Symbol Alias	IKAP, TOT1, ELP1, IKI3
Approved Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Previous Name	dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type III)
Location	9q31
Position	chr9:111629797-111696608, -
External Links	HGNC: 5959 Entrez Gene: 8518 Ensembl: ENSG00000070061 UCSC: uc004bdm.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component	IDA[11714725]	690
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[11818576]; TAS[11714725]	42
GO:0006368	transcription elongation from RNA polymerase II promoter	Biological Process	IDA[11714725]	10
GO:0006461	protein complex assembly	Biological Process	TAS[9751059]	28
GO:0003677	DNA binding	Molecular Function	IDA[11714725]	220
GO:0004871	signal transducer activity	Molecular Function	TAS[9751059]	49
GO:0005515	protein binding	Molecular Function		910
GO:0005730	nucleolus	Cellular Component	IDA[11714725]	243
GO:0008607	phosphorylase kinase regulator activity	Molecular Function	IDA[11818576]	2
GO:0016591	DNA-directed RNA polymerase II, holoenzyme	Cellular Component	IDA[11714725]	3
GO:0030335	positive regulation of cell migration	Biological Process		29
GO:0033588	Elongator holoenzyme complex	Cellular Component		2
GO:0006468	protein phosphorylation	Biological Process	TAS[9751059]	53
GO:0006955	immune response	Biological Process	TAS[9751059]	45
GO:0007165	signal transduction	Biological Process	TAS[9751059]	171
GO:0008023	transcription elongation factor complex	Cellular Component	IDA[11714725]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IKBKAP (count: 8)

Gene Symbol	Pathway Count	Pathway List
ELP2	8	cytoplasm; regulation of transcription from RNA polymerase II promoter; transcription elongation from RNA polymerase II promoter; DNA binding; nucleolus; DNA-directed RNA polymerase II, holoenzyme; Elongator holoenzyme complex; transcription elongation factor complex;
MAPK1	6	cytoplasm; DNA binding; protein binding; nucleolus; positive regulation of cell migration; signal transduction;
AIP	5	cytoplasm; signal transducer activity; protein binding; nucleolus; signal transduction;
ILK	5	cytoplasm; signal transducer activity; protein binding; positive regulation of cell migration; protein phosphorylation;
NEK6	5	cytoplasm; signal transducer activity; protein binding; protein phosphorylation; signal transduction;
PGR	5	cytoplasm; DNA binding; protein binding; nucleolus; signal transduction;
PRKCB	5	cytoplasm; regulation of transcription from RNA polymerase II promoter; protein binding; protein phosphorylation; signal transduction;
SSRP1	5	cytoplasm; transcription elongation from RNA polymerase II promoter; DNA binding; protein binding; nucleolus;

Genes shared at least 2 KEGG pathways with IKBKAP (count: 0)

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Region: chr9:111629797..111696608 View in gBrowse