ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CACYBP
Symbol Alias	SIP, S100A6BP
Approved Name	calcyclin binding protein
Location	1q24-q25
Position	chr1:174968300-174981163, +
External Links	HGNC: 30423 Entrez Gene: 27101 Ensembl: ENSG00000116161 UCSC: uc001gkj.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030877	beta-catenin destruction complex	Cellular Component	IDA[16085652]	4
GO:0007568	aging	Biological Process		29
GO:0005737	cytoplasm	Cellular Component		690
GO:0005641	nuclear envelope lumen	Cellular Component		2
GO:0005515	protein binding	Molecular Function	IPI[16085652]	910
GO:0071277	cellular response to calcium ion	Biological Process		4
GO:0060548	negative regulation of cell death	Biological Process		5
GO:0060416	response to growth hormone stimulus	Biological Process		2
GO:0055007	cardiac muscle cell differentiation	Biological Process		4
GO:0045740	positive regulation of DNA replication	Biological Process		7
GO:0044297	cell body	Cellular Component		3
GO:0043005	neuron projection	Cellular Component		35
GO:0042803	protein homodimerization activity	Molecular Function	IPI[16085652]	113

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...

Genes shared at least 5 GO terms with CACYBP (count: 0)

Genes shared at least 2 KEGG pathways with CACYBP (count: 0)

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Region: chr1:174968300..174981163 View in gBrowse