ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ABCG4
Symbol Alias	WHITE2
Approved Name	ATP-binding cassette, sub-family G (WHITE), member 4
Name Alias	putative ABC transporter, "ATP-binding cassette, subfamily G, member 4"
Location	11q23
Position	chr11:119019722-119033375, +
External Links	HGNC: 13884 Entrez Gene: 64137 Ensembl: ENSG00000172350 UCSC: uc001pvs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0033344	cholesterol efflux	Biological Process	TAS[16682745]	8
GO:0042803	protein homodimerization activity	Molecular Function	IDA[16870176]	113
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[16870176]	68
GO:0055085	transmembrane transport	Biological Process		82
GO:0005886	plasma membrane	Cellular Component		772
GO:0016021	integral to membrane	Cellular Component		845
GO:0016887	ATPase activity	Molecular Function		14
GO:0017127	cholesterol transporter activity	Molecular Function		5
GO:0005524	ATP binding	Molecular Function		228

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa02010	ABC transporters	7	The ATP-binding cassette (ABC) transporters form one of the ...... The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). More...

Genes shared at least 5 GO terms with ABCG4 (count: 2)

Gene Symbol	Pathway Count	Pathway List
ABCA1	5	cholesterol efflux; plasma membrane; ATPase activity; cholesterol transporter activity; ATP binding;
ABCG2	5	protein homodimerization activity; transmembrane transport; plasma membrane; integral to membrane; ATP binding;

Genes shared at least 2 KEGG pathways with ABCG4 (count: 0)

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Region: chr11:119019722..119033375 View in gBrowse