ADHDgene Database

Gene Report

Basic Info

Approved Symbol	USP46
Symbol Alias	FLJ12552
Approved Name	ubiquitin specific peptidase 46
Previous Name	ubiquitin specific protease 46
Location	4q12
Position	chr4:53457126-53525502, -
External Links	HGNC: 20075 Entrez Gene: 64854 Ensembl: ENSG00000109189 UCSC: uc003gzn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_2	chr4:53180000-53910000 (NCBI Build 35 (hg17))	730000	4q12	Duplication	Paternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004221	ubiquitin thiolesterase activity	Molecular Function	IDA[19075014]	12
GO:0004843	ubiquitin-specific protease activity	Molecular Function	IDA[19075014]	9
GO:0005515	protein binding	Molecular Function	IPI[19075014]	910
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process		25
GO:0007610	behavior	Biological Process		10
GO:0016579	protein deubiquitination	Biological Process	IDA[19075014]	6
GO:0032228	regulation of synaptic transmission, GABAergic	Biological Process		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with USP46 (count: 3)

Gene Symbol	Pathway Count	Pathway List
USP10	5	ubiquitin thiolesterase activity; ubiquitin-specific protease activity; protein binding; ubiquitin-dependent protein catabolic process; protein deubiquitination;
USP22	5	ubiquitin thiolesterase activity; ubiquitin-specific protease activity; protein binding; ubiquitin-dependent protein catabolic process; protein deubiquitination;
USP28	5	ubiquitin thiolesterase activity; ubiquitin-specific protease activity; protein binding; ubiquitin-dependent protein catabolic process; protein deubiquitination;

Genes shared at least 2 KEGG pathways with USP46 (count: 0)

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Region: chr4:53457126..53525502 View in gBrowse