ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NPAS3
Symbol Alias	MOP6, PASD6, bHLHe12
Approved Name	neuronal PAS domain protein 3
Location	14q13.1
Position	chr14:33404139-34273382, 1
External Links	HGNC: 19311 Entrez Gene: 64067 Ensembl: ENSG00000151322 UCSC: uc001wru.3
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Weber H, 2011	1 SNP showed significant association with ADHD before Bonferroni correction	Significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs17455703	chr14:33489372(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042711	maternal behavior	biological process	IEA	3
GO:0004871	signal transducer activity	molecular function	IEA	56
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	ISS	89
GO:0003677	DNA binding	molecular function	IEA	257
GO:0005730	nucleolus	cellular component	IDA	271
GO:0007626	locomotory behavior	biological process	IEA	26
GO:0005634	nucleus	cellular component	IDA	877
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0035176	social behavior	biological process	IEA	9
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0046983	protein dimerization activity	molecular function	IEA	28

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NPAS3 (count: 17)

Gene Symbol	Pathway Count	Pathway List
AHRR	6	signal transducer activity; DNA binding; nucleus; cytoplasm; transcription, DNA-dependent; protein dimerization activity;
MAPK1	6	positive regulation of transcription, DNA-dependent; DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
TBX1	6	positive regulation of transcription, DNA-dependent; DNA binding; nucleus; social behavior; transcription, DNA-dependent; protein dimerization activity;
SOX8	5	positive regulation of transcription, DNA-dependent; DNA binding; nucleus; cytoplasm; transcription, DNA-dependent;
EBF1	5	positive regulation of transcription, DNA-dependent; DNA binding; nucleus; transcription, DNA-dependent; protein dimerization activity;
HINFP	5	positive regulation of transcription, DNA-dependent; DNA binding; nucleolus; nucleus; transcription, DNA-dependent;
ID2	5	positive regulation of transcription, DNA-dependent; nucleolus; nucleus; cytoplasm; protein dimerization activity;
ATXN1	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
XRCC5	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
HOXB1	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
ZNF263	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
BCLAF1	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
ZNF367	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
PNN	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
ZNF77	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
TCF25	5	DNA binding; nucleolus; nucleus; cytoplasm; transcription, DNA-dependent;
POU2F3	5	nucleolus; nucleus; cytoplasm; transcription, DNA-dependent; protein dimerization activity;

Genes shared at least 2 KEGG pathways with NPAS3 (count: 0)

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Region: chr14:33404139..34273382 View in gBrowse