ADHDgene Database

Gene Report

Basic Info

Approved Symbol	APLP2
Previous Symbol	APPL2
Symbol Alias	APPH
Approved Name	amyloid beta (A4) precursor-like protein 2
Location	11q24
Position	chr11:129939716-130014706, +
External Links	HGNC: 598 Entrez Gene: 334 Ensembl: ENSG00000084234 UCSC: uc010sby.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016021	integral to membrane	Cellular Component	NAS[8485127]	845
GO:0009790	embryo development	Biological Process		17
GO:0008203	cholesterol metabolic process	Biological Process		16
GO:0008201	heparin binding	Molecular Function		26
GO:0042802	identical protein binding	Molecular Function	IPI[16193067]	70
GO:0030901	midbrain development	Biological Process		5
GO:0030900	forebrain development	Biological Process		9
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0050885	neuromuscular process controlling balance	Biological Process		8
GO:0046914	transition metal ion binding	Molecular Function		3
GO:0043393	regulation of protein binding	Biological Process		4
GO:0001967	suckling behavior	Biological Process		4
GO:0003677	DNA binding	Molecular Function	NAS[7702756]	220
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function		10
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component	IDA[7702756]	770
GO:0005886	plasma membrane	Cellular Component		772
GO:0006878	cellular copper ion homeostasis	Biological Process		1
GO:0007176	regulation of epidermal growth factor-activated receptor activity	Biological Process		2
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	NAS[8220435]	72
GO:0007617	mating behavior	Biological Process		4
GO:0007626	locomotory behavior	Biological Process		24

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with APLP2 (count: 3)

Gene Symbol	Pathway Count	Pathway List
APOA1	6	cholesterol metabolic process; identical protein binding; protein binding; nucleus; plasma membrane; G-protein coupled receptor signaling pathway;
ERBB2	5	integral to membrane; identical protein binding; protein binding; nucleus; plasma membrane;
SREBF1	5	integral to membrane; cholesterol metabolic process; DNA binding; protein binding; nucleus;

Genes shared at least 2 KEGG pathways with APLP2 (count: 0)

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Region: chr11:129939716..130014706 View in gBrowse