ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ST3GAL4
Previous Symbol	CGS23, SIAT4, NANTA3, SIAT4C
Symbol Alias	STZ, SAT3, FLJ11867
Approved Name	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Previous Name	"sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)"
Name Alias	"ST3Gal IV"
Location	11q23-q24
Position	chr11:126225535-126310239, 1
External Links	HGNC: 10864 Entrez Gene: 6484 Ensembl: ENSG00000110080 UCSC: uc001qds.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000139	Golgi membrane	cellular component	TAS	106
GO:0032580	Golgi cisterna membrane	cellular component	IEA	21
GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	molecular function	IEA	1
GO:0016266	O-glycan processing	biological process	TAS	5
GO:0005975	carbohydrate metabolic process	biological process	TAS	59
GO:0043687	post-translational protein modification	biological process	TAS	42
GO:0030173	integral to Golgi membrane	cellular component	IEA	8
GO:0044267	cellular protein metabolic process	biological process	TAS	78
GO:0042339	keratan sulfate metabolic process	biological process	TAS	9
GO:0018146	keratan sulfate biosynthetic process	biological process	TAS	8
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	23
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS	27
GO:0047288	monosialoganglioside sialyltransferase activity	molecular function	IEA	1
GO:0005576	extracellular region	cellular component	IEA	267

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa01030	Glycan structures - biosynthesis 1	25
hsa01031	Glycan structures - biosynthesis 2	11
hsa00601	Glycosphingolipid biosynthesis - lactoseries	1
hsa00533	Keratan sulfate biosynthesis	5

Genes shared at least 5 GO terms with ST3GAL4 (count: 14)

Gene Symbol	Pathway Count	Pathway List
B4GALT6	10	Golgi membrane; Golgi cisterna membrane; carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process; protein N-linked glycosylation via asparagine;
B4GALT4	10	Golgi membrane; Golgi cisterna membrane; carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process; protein N-linked glycosylation via asparagine;
B3GNT1	7	Golgi membrane; carbohydrate metabolic process; integral to Golgi membrane; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process;
GALNT1	6	Golgi membrane; Golgi cisterna membrane; O-glycan processing; post-translational protein modification; cellular protein metabolic process; extracellular region;
CHST6	6	Golgi membrane; carbohydrate metabolic process; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process;
CHST5	6	Golgi membrane; carbohydrate metabolic process; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process;
OMD	6	carbohydrate metabolic process; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process; extracellular region;
OGN	6	carbohydrate metabolic process; keratan sulfate metabolic process; keratan sulfate biosynthetic process; glycosaminoglycan metabolic process; small molecule metabolic process; extracellular region;
MGAT1	5	Golgi membrane; carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; protein N-linked glycosylation via asparagine;
CHST9	5	Golgi membrane; carbohydrate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; extracellular region;
CHPF	5	Golgi membrane; Golgi cisterna membrane; carbohydrate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process;
MAN2A2	5	Golgi membrane; carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; protein N-linked glycosylation via asparagine;
ST8SIA3	5	Golgi membrane; post-translational protein modification; integral to Golgi membrane; cellular protein metabolic process; protein N-linked glycosylation via asparagine;
ARSB	5	carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with ST3GAL4 (count: 4)

Gene Symbol	Pathway Count	Pathway List
B3GNT1	3	Glycan structures - biosynthesis 1; Glycan structures - biosynthesis 2; Keratan sulfate biosynthesis;
B3GNT6	3	Glycan structures - biosynthesis 1; Glycan structures - biosynthesis 2; Keratan sulfate biosynthesis;
B4GALT4	3	Glycan structures - biosynthesis 1; Glycan structures - biosynthesis 2; Keratan sulfate biosynthesis;
CHST6	2	Glycan structures - biosynthesis 1; Keratan sulfate biosynthesis;

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Region: chr11:126225535..126310239 View in gBrowse