ADHDgene Database

Gene Report

Basic Info

Approved Symbol	NRXN2
Approved Name	neurexin 2
Name Alias	neurexin II
Location	11q13
Position	chr11:64373646-64490660, -
External Links	HGNC: 8009 Entrez Gene: 9379 Ensembl: ENSG00000110076 UCSC: uc001oar.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

ID	Name	Type	No. of Genes in ADHDgene
GO:0097118	neuroligin clustering	Biological Process	2
GO:0097116	gephyrin clustering	Biological Process	2
GO:0097119	postsynaptic density protein 95 clustering	Biological Process	3
GO:0007155	cell adhesion	Biological Process	86
GO:0007269	neurotransmitter secretion	Biological Process	18
GO:0005246	calcium channel regulator activity	Molecular Function	10
GO:0050839	cell adhesion molecule binding	Molecular Function	9
GO:0097104	postsynaptic membrane assembly	Biological Process	3
GO:0016021	integral to membrane	Cellular Component	845
GO:0046872	metal ion binding	Molecular Function	170

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with NRXN2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
NRXN1	10	neuroligin clustering; gephyrin clustering; postsynaptic density protein 95 clustering; cell adhesion; neurotransmitter secretion; calcium channel regulator activity; cell adhesion molecule binding; postsynaptic membrane assembly; integral to membrane; metal ion binding;

Genes shared at least 2 KEGG pathways with NRXN2 (count: 0)

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Region: chr11:64373646..64490660 View in gBrowse