ADHDgene Database

Gene Report

Basic Info

Approved Symbol	RNASEH2C
Symbol Alias	AYP1, AGS3
Approved Name	ribonuclease H2, subunit C
Name Alias	Aicardi-Goutieres syndrome 3
Location	11q13.1
Position	chr11:65482367-65488418, -
External Links	HGNC: 24116 Entrez Gene: 84153 Ensembl: ENSG00000172922 UCSC: uc001ofn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 3)

ID	Name	Type	No. of Genes in ADHDgene
GO:0032299	ribonuclease H2 complex	Cellular Component	1
GO:0006401	RNA catabolic process	Biological Process	1
GO:0005634	nucleus	Cellular Component	770

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03030	DNA replication	7	A complex network of interacting proteins and enzymes is req...... A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA. More...

Genes shared at least 5 GO terms with RNASEH2C (count: 0)

Genes shared at least 2 KEGG pathways with RNASEH2C (count: 0)

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Region: chr11:65482367..65488418 View in gBrowse