ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GANAB
Symbol Alias	GluII, G2AN, KIAA0088
Approved Name	glucosidase, alpha; neutral AB
Location	11q12.3
Position	chr11:62392298-62414104, -
External Links	HGNC: 4138 Entrez Gene: 23193 Ensembl: ENSG00000089597 UCSC: uc001nua.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	No. of Genes in ADHDgene
GO:0043687	post-translational protein modification	Biological Process	37
GO:0042470	melanosome	Cellular Component	22
GO:0033919	glucan 1,3-alpha-glucosidase activity	Molecular Function	1
GO:0030246	carbohydrate binding	Molecular Function	28
GO:0044267	cellular protein metabolic process	Biological Process	64
GO:0005788	endoplasmic reticulum lumen	Cellular Component	33
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process	24
GO:0017177	glucosidase II complex	Cellular Component	1
GO:0006457	protein folding	Biological Process	28
GO:0005794	Golgi apparatus	Cellular Component	157

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with GANAB (count: 4)

Gene Symbol	Pathway Count	Pathway List
CANX	6	post-translational protein modification; melanosome; cellular protein metabolic process; endoplasmic reticulum lumen; protein N-linked glycosylation via asparagine; protein folding;
PDIA3	6	post-translational protein modification; melanosome; cellular protein metabolic process; endoplasmic reticulum lumen; protein N-linked glycosylation via asparagine; protein folding;
EDEM2	5	post-translational protein modification; cellular protein metabolic process; endoplasmic reticulum lumen; protein N-linked glycosylation via asparagine; protein folding;
EDEM3	5	post-translational protein modification; cellular protein metabolic process; endoplasmic reticulum lumen; protein N-linked glycosylation via asparagine; protein folding;

Genes shared at least 2 KEGG pathways with GANAB (count: 10)

Gene Symbol	Pathway Count	Pathway List
MAN1A1	3	N-Glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum;
STT3A	3	N-Glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum;
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG2	2	N-Glycan biosynthesis; Metabolic pathways;
ALG8	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
DPAGT1	2	N-Glycan biosynthesis; Metabolic pathways;
MAN2A2	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT1	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT4B	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr11:62392298..62414104 View in gBrowse