Gene Report
Basic Info
Approved Symbol |
PRG2
|
Symbol Alias |
MBP, BMPG |
Approved Name |
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Location |
11q12 |
Position |
chr11:57154267-57158130, - |
External Links |
HGNC: 9362
Entrez Gene: 5553
Ensembl: ENSG00000186652
UCSC: uc002lpw.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 6)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa05310 |
Asthma |
3 |
Asthma is a complex syndrome with many clinical phenotypes i......
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
More...
|
Genes shared at least 5 GO terms with PRG2 (count: 0)
Genes shared at least 2 KEGG pathways with PRG2 (count: 0)
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