ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ESAM
Symbol Alias	W117m
Approved Name	endothelial cell adhesion molecule
Location	11q24.2
Position	chr11:124622477-124632223, -
External Links	HGNC: 17474 Entrez Gene: 90952 Ensembl: ENSG00000149564 UCSC: uc001qav.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 7)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 7)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component	772
GO:0005912	adherens junction	Cellular Component	9
GO:0005923	tight junction	Cellular Component	15
GO:0007156	homophilic cell adhesion	Biological Process	27
GO:0007596	blood coagulation	Biological Process	83
GO:0016021	integral to membrane	Cellular Component	845
GO:0050900	leukocyte migration	Biological Process	13

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...
hsa04670	Leukocyte transendothelial migration	22	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...

Genes shared at least 5 GO terms with ESAM (count: 2)

Gene Symbol	Pathway Count	Pathway List
AMICA1	5	plasma membrane; tight junction; blood coagulation; integral to membrane; leukocyte migration;
JAM3	5	plasma membrane; tight junction; blood coagulation; integral to membrane; leukocyte migration;

Genes shared at least 2 KEGG pathways with ESAM (count: 3)

Gene Symbol	Pathway Count	Pathway List
CLDN5	2	Cell adhesion molecules (CAMs); Leukocyte transendothelial migration;
ITGAL	2	Cell adhesion molecules (CAMs); Leukocyte transendothelial migration;
JAM3	2	Cell adhesion molecules (CAMs); Leukocyte transendothelial migration;

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Region: chr11:124622477..124632223 View in gBrowse