ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ALG8
Symbol Alias	MGC2840
Approved Name	asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
Previous Name	asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
Location	11pter-p15.5
Position	chr11:77811982-77850706, -
External Links	HGNC: 23161 Entrez Gene: 79053 Ensembl: ENSG00000159063 UCSC: uc001oza.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	Biological Process		8
GO:0006487	protein N-linked glycosylation	Biological Process	IMP[12480927]	2
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0000033	alpha-1,3-mannosyltransferase activity	Molecular Function	IMP[12480927]	2
GO:0016021	integral to membrane	Cellular Component		845
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0043687	post-translational protein modification	Biological Process		37
GO:0044267	cellular protein metabolic process	Biological Process		64

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with ALG8 (count: 6)

Gene Symbol	Pathway Count	Pathway List
ALG2	7	dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; alpha-1,3-mannosyltransferase activity; integral to membrane; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
DPAGT1	7	dolichol-linked oligosaccharide biosynthetic process; protein N-linked glycosylation; endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
ALG10	6	dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
ALG9	6	dolichol-linked oligosaccharide biosynthetic process; endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
LMAN1	5	endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
STT3A	5	endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;

Genes shared at least 2 KEGG pathways with ALG8 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG2	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
DPAGT1	2	N-Glycan biosynthesis; Metabolic pathways;
GANAB	2	N-Glycan biosynthesis; Metabolic pathways;
MAN1A1	2	N-Glycan biosynthesis; Metabolic pathways;
MAN2A2	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT1	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT4B	2	N-Glycan biosynthesis; Metabolic pathways;
STT3A	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr11:77811982..77850706 View in gBrowse