ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SLC22A8
Symbol Alias	OAT3
Approved Name	solute carrier family 22 (organic anion transporter), member 8
Location	11q12.3
Position	chr11:62760296-62783317, -
External Links	HGNC: 10972 Entrez Gene: 9376 Ensembl: ENSG00000149452 UCSC: uc001nwo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005080	protein kinase C binding	Molecular Function		9
GO:0005452	inorganic anion exchanger activity	Molecular Function	IDA[15037815]	6
GO:0005886	plasma membrane	Cellular Component		772
GO:0008514	organic anion transmembrane transporter activity	Molecular Function		5
GO:0031427	response to methotrexate	Biological Process		3
GO:0034635	glutathione transport	Biological Process		1
GO:0055085	transmembrane transport	Biological Process		82
GO:0009636	response to toxin	Biological Process		15
GO:0015651	quaternary ammonium group transmembrane transporter activity	Molecular Function		1
GO:0016021	integral to membrane	Cellular Component		845
GO:0016323	basolateral plasma membrane	Cellular Component	IDA[15037815]	29

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04976	Bile secretion	13	Bile is a vital secretion, essential for digestion and absor...... Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. More...

Genes shared at least 5 GO terms with SLC22A8 (count: 2)

Gene Symbol	Pathway Count	Pathway List
SLC22A6	6	inorganic anion exchanger activity; plasma membrane; organic anion transmembrane transporter activity; response to methotrexate; transmembrane transport; basolateral plasma membrane;
SLC4A2	5	inorganic anion exchanger activity; plasma membrane; transmembrane transport; integral to membrane; basolateral plasma membrane;

Genes shared at least 2 KEGG pathways with SLC22A8 (count: 0)

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Region: chr11:62760296..62783317 View in gBrowse